| Gene Symbol |
TCF7
|
| Entrez Gene |
6932
|
| Alt Symbol |
TCF-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor 7 (T-cell specific, HMG-box)
|
| Other Description |
T-cell-specific transcription factor 1|transcription factor 7
|
| Swissprots |
Q9UKI4 P36402 Q86WR9 B3KSH3
|
| Accessions |
AAF00616 CAB56795 CAY55999 CAY56000 CAY56001 CAY56002 CBX53858 CBX53859 CBX53860 CBX53861 CBX53862 EAW62277 EAW62278 EAW62279 EAW62280 P36402 AK057580 BAG51937 AK093530 BAG52735 AK093683 BAG52748 AK131428 AK310591 AL832816 AL834166 BC048769 AAH48769 BC072023 AAH72023 DA627229 DB127975 DB137814 DB145426 EU446661 ABZ92190 X59869 CAA42526 X59870 CAA42527 X59871 CAA42528 Z47361 CAA87439 Z47362 CAA87440 Z47363 CAA87441 Z47364 CAA87442 XM_006714678 XP_006714741 XM_006714679 XP_006714742 XM_006714680 XP_006714743 XM_006714682 XP_006714745 XM_006714684 XP_006714747 XM_006714685 XP_006714748 XM_006714686 XP_006714749 XM_006714687 XP_006714750 XM_011543604 XP_011541906 XM_011543605 XP_011541907 XM_011543606 XP_011541908 XM_011543607 XP_011541909 XM_011543608 XP_011541910 XM_011543609 XP_011541911 XM_011543610 XP_011541912 XM_011543611 XP_011541913 XM_011543612 XP_011541914 XM_011543613 XP_011541915 XR_948292 XR_948293 XR_948294 NM_001134851 NP_001128323 NM_003202 NP_003193 NM_201632 NP_963963 NM_201634 NP_963965 NM_213648 NP_998813 NR_033449 NM_001134852
|
| Function |
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. {ECO:0000269|PubMed:10489374}.
|
| Top Pathways |
Hippo signaling pathway, Wnt signaling pathway, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Thyroid cancer, Prostate cancer
|