PPP4C
| Gene Symbol | PPP4C |
|---|---|
| Entrez Gene | 5531 |
| Alt Symbol | PP-X, PP4, PP4C, PPH3, PPP4, PPX |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 4, catalytic subunit |
| Other Description | protein phosphatase 4 (formerly X), catalytic subunit|protein phosphatase X, catalytic subunit|serine/threonine-protein phosphatase 4 catalytic subunit |
| Swissprots | P60510 P33172 |
| Accessions | EAW79928 EAW79929 EAW79930 EAW79931 P60510 AA765831 AF097996 AAC96318 AL519181 BC001416 AAH01416 BG705710 BG706310 BG741669 BQ220878 BT019746 AAV38551 DQ891947 ABM82873 DQ895134 ABM86060 X70218 CAA49753 XM_006721061 XP_006721124 NM_001303503 NP_001290432 NM_001303504 NP_001290433 NM_001303506 NP_001290435 NM_001303507 NP_001290436 NM_002720 NP_002711 |
| Function | Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. {ECO:0000250, ECO:0000269|PubMed:11698396, ECO:0000269| |
| Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
| Top Pathways | Glucagon signaling pathway |
PPX CRISPR/Cas9 KO Plasmid (h) - sc-403212 from Santa Cruz Biotechnology
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PPX HDR Plasmid (h) - sc-403212-HDR from Santa Cruz Biotechnology
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PPX Double Nickase Plasmid (h) - sc-403212-NIC from Santa Cruz Biotechnology
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PPX Double Nickase Plasmid (h2) - sc-403212-NIC-2 from Santa Cruz Biotechnology
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PPX CRISPR Activation Plasmid (h) - sc-403212-ACT from Santa Cruz Biotechnology
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PPX CRISPR Activation Plasmid (h2) - sc-403212-ACT-2 from Santa Cruz Biotechnology
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PPX Lentiviral Activation Particles (h) - sc-403212-LAC from Santa Cruz Biotechnology
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PPX Lentiviral Activation Particles (h2) - sc-403212-LAC-2 from Santa Cruz Biotechnology
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PPX siRNA (h) - sc-39202 from Santa Cruz Biotechnology
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PPX shRNA Plasmid (h) - sc-39202-SH from Santa Cruz Biotechnology
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PPX shRNA (h) Lentiviral Particles - sc-39202-V from Santa Cruz Biotechnology
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PPP4C RNAi - H00005531-R04 from Novus Biologicals
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MISSION® esiRNA - EHU054021 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0666 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0665 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0664 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17309 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17309 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01715 from Sigma-Aldrich
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PPP4C siRNA (Human) - CRH3710 from Cohesion Biosciences
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PPX CRISPR/Cas9 KO Plasmid (h2) - sc-403212-KO-2 from Santa Cruz Biotechnology
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PPX HDR Plasmid (h2) - sc-403212-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PPP4C (NM_002720.1) - SHH381592 from Creative biogene
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shRNA set against Human PPP4C(NM_002720.1) - SHR135696 from Creative biogene
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Human PPP4C siRNA - orb264212 from Biorbyt
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