| Gene Symbol | St6galnac3 |
|---|---|
| Entrez Gene | 20447 |
| Alt Symbol | Siat7c |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 |
| Other Description | SIAT7-C|ST6GalNAc III|ST6GalNAcIII|STY|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3|galNAc alpha-2,6-sialyltransferase III|sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C|sialyltransferase 7C |
| Swissprots | Q9JHP5 Q9WUV2 |
| Accessions | CAB95031 EDL11908 Q9WUV2 AK021356 AK034804 BAC28836 AK085642 BC058387 AAH58387 BC131987 AAI31988 BC132317 AAI32318 Y11342 CAA72181 XM_006501219 XP_006501282 XM_006501220 XP_006501283 XM_006501221 XP_006501284 XM_006501222 XP_006501285 XM_011240053 XP_011238355 XM_011240054 XP_011238356 NM_011372 NP_035502 |
| Function | Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins. {ECO:0000269|PubMed:10207017}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Tissue Specificity | High expression in brain, lung and heart and to a lesser extent in kidney, mammary gland, spleen, testis and thymus. {ECO:0000269|PubMed:10207017}. |
| Top Pathways | Glycosphingolipid biosynthesis - ganglio series |