Gene Symbol | St6galnac3 |
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Entrez Gene | 20447 |
Alt Symbol | Siat7c |
Species | Mouse |
Gene Type | protein-coding |
Description | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 |
Other Description | SIAT7-C|ST6GalNAc III|ST6GalNAcIII|STY|alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3|galNAc alpha-2,6-sialyltransferase III|sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C|sialyltransferase 7C |
Swissprots | Q9JHP5 Q9WUV2 |
Accessions | CAB95031 EDL11908 Q9WUV2 AK021356 AK034804 BAC28836 AK085642 BC058387 AAH58387 BC131987 AAI31988 BC132317 AAI32318 Y11342 CAA72181 XM_006501219 XP_006501282 XM_006501220 XP_006501283 XM_006501221 XP_006501284 XM_006501222 XP_006501285 XM_011240053 XP_011238355 XM_011240054 XP_011238356 NM_011372 NP_035502 |
Function | Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins. {ECO:0000269|PubMed:10207017}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
Tissue Specificity | High expression in brain, lung and heart and to a lesser extent in kidney, mammary gland, spleen, testis and thymus. {ECO:0000269|PubMed:10207017}. |
Top Pathways | Glycosphingolipid biosynthesis - ganglio series |
Sialyltransferase 7C CRISPR/Cas9 KO Plasmid (m) - sc-422940 from Santa Cruz Biotechnology
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Sialyltransferase 7C HDR Plasmid (m) - sc-422940-HDR from Santa Cruz Biotechnology
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Sialyltransferase 7C Double Nickase Plasmid (m) - sc-422940-NIC from Santa Cruz Biotechnology
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Sialyltransferase 7C Double Nickase Plasmid (m2) - sc-422940-NIC-2 from Santa Cruz Biotechnology
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Sialyltransferase 7C CRISPR Activation Plasmid (m) - sc-422940-ACT from Santa Cruz Biotechnology
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Sialyltransferase 7C CRISPR Activation Plasmid (m2) - sc-422940-ACT-2 from Santa Cruz Biotechnology
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Sialyltransferase 7C Lentiviral Activation Particles (m) - sc-422940-LAC from Santa Cruz Biotechnology
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Sialyltransferase 7C Lentiviral Activation Particles (m2) - sc-422940-LAC-2 from Santa Cruz Biotechnology
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Sialyltransferase 7C siRNA (m) - sc-63019 from Santa Cruz Biotechnology
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Sialyltransferase 7C shRNA Plasmid (m) - sc-63019-SH from Santa Cruz Biotechnology
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Sialyltransferase 7C shRNA (m) Lentiviral Particles - sc-63019-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU215781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42127 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42127 from Sigma-Aldrich
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ST6GALNAC3 siRNA (Mouse) - CRM3722 from Cohesion Biosciences
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ST6GALNAC3 - MBS8218779 from MyBioSource
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shRNA set against Mouse ST6GALNAC3 (NM_011372.2) - SHH418936 from Creative biogene
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shRNA set against Mouse St6galnac3(NM_011372.2) - SHL038580 from Creative biogene
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Mouse ST6GALNAC3 siRNA - orb283198 from Biorbyt
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ST6GALNAC3 shRNA Plasmid (Mouse) - CHM3722 from Cohesion Biosciences
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ST6GALNAC3 miRNA 3'UTR clone - MiUTR1M-11281 from Creative biogene
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