Gene Symbol | IGBP1 |
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Entrez Gene | 3476 |
Alt Symbol | ALPHA-4, IBP1 |
Species | Human |
Gene Type | protein-coding |
Description | immunoglobulin (CD79A) binding protein 1 |
Other Description | B cell signal transduction molecule alpha 4|B-cell signal transduction molecule alpha 4|CD79a-binding protein 1|bA351K23.1 (immunoglobulin binding protein 1 (CD79A) )|immunoglobulin-binding protein 1|protein alpha-4|protein phosphatase 2/4/6 regulatory subunit|protein phosphatase 2A, regulatory subunit alpha-4|renal carcinoma antigen NY-REN-16 |
Swissprots | Q8TAB2 P78318 |
Accessions | ABK41907 EAX05355 EAX05356 P78318 AK054596 BAG51396 AK315660 BAG38026 BC004137 AAH04137 BT006736 AAP35382 CR456782 CAG33063 DQ892322 ABM83248 DQ895524 ABM86450 Y08915 CAA70119 XR_938398 XR_938399 NM_001551 NP_001542 |
Function | Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. {ECO:0000269|PubMed:19818709, ECO:0000269|PubMed:23591866}. |
Subcellular Location | Cytoplasm {ECO:0000305}. |
Tissue Specificity | Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. |
Alpha 4 CRISPR/Cas9 KO Plasmid (h) - sc-406731 from Santa Cruz Biotechnology
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Alpha 4 HDR Plasmid (h) - sc-406731-HDR from Santa Cruz Biotechnology
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Alpha 4 Double Nickase Plasmid (h) - sc-406731-NIC from Santa Cruz Biotechnology
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Alpha 4 Double Nickase Plasmid (h2) - sc-406731-NIC-2 from Santa Cruz Biotechnology
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Alpha 4 CRISPR Activation Plasmid (h) - sc-406731-ACT from Santa Cruz Biotechnology
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Alpha 4 CRISPR Activation Plasmid (h2) - sc-406731-ACT-2 from Santa Cruz Biotechnology
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Alpha 4 Lentiviral Activation Particles (h) - sc-406731-LAC from Santa Cruz Biotechnology
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Alpha 4 Lentiviral Activation Particles (h2) - sc-406731-LAC-2 from Santa Cruz Biotechnology
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Alpha 4 siRNA (h) - sc-44648 from Santa Cruz Biotechnology
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Alpha 4 shRNA Plasmid (h) - sc-44648-SH from Santa Cruz Biotechnology
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Alpha 4 shRNA (h) Lentiviral Particles - sc-44648-V from Santa Cruz Biotechnology
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IGBP1 RNAi - H00003476-R01 from Novus Biologicals
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MISSION® esiRNA - EHU060141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10511 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10511 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02385 from Sigma-Aldrich
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IGBP1 siRNA (Human) - CRH2349 from Cohesion Biosciences
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IGBP1 - MBS8213483 from MyBioSource
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Alpha 4 CRISPR/Cas9 KO Plasmid (h2) - sc-406731-KO-2 from Santa Cruz Biotechnology
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Alpha 4 HDR Plasmid (h2) - sc-406731-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human IGBP1 (NM_001551.2) - SHH317389 from Creative biogene
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IGBP1 shRNA Plasmid (Human) - CHH2349 from Cohesion Biosciences
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IGBP1 miRNA 3'UTR clone - MiUTR3H-02588 from Creative biogene
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