| Gene Symbol | PRNP |
|---|---|
| Entrez Gene | 102127229 |
| Alt Symbol | PRP, PrP27-30, PrP33-35C |
| Species | Monkey |
| Gene Type | protein-coding |
| Description | prion protein |
| Other Description | major prion protein |
| Swissprots | Q60HD4 P40254 P67992 |
| Accessions | AAC50087 P67992 AB125193 BAD51981 AB174659 BAE91721 NM_001287629 NP_001274558 XM_005568413 XP_005568470 XM_005568414 XP_005568471 XM_005568415 XP_005568472 |
| Function | May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis (By similarity). {ECO:0000250}. |
| Top Pathways | Prion diseases |