Gene Symbol | EMG1 |
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Entrez Gene | 10436 |
Alt Symbol | C2F, Grcc2f, NEP1 |
Species | Human |
Gene Type | protein-coding |
Description | EMG1 N1-specific pseudouridine methyltransferase |
Other Description | 18S rRNA (pseudouridine(1248)-N1)-methyltransferase|18S rRNA (pseudouridine-N1-)-methyltransferase NEP1|18S rRNA Psi1248 methyltransferase|EMG1 nucleolar protein homolog|essential for mitotic growth 1|ribosomal RNA small subunit methyltransferase NEP1|ribosome biogenesis protein NEP1 |
Swissprots | O00726 Q92979 O00675 |
Accessions | AAB51325 EAW88694 EAW88695 EAW88696 EAW88697 EAW88698 Q92979 AA314580 AI394112 AK291597 BAF84286 AK298207 BAG60477 AK298745 BAG60889 AK307177 BC055314 AAH55314 BM709304 BQ015307 CD704778 DA070200 DC403138 HQ447756 ADQ32241 U56427 U72514 AAC51641 XM_011520907 XP_011519209 NM_006331 NP_006322 |
Function | S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). {ECO:0000250|UniProtKB:Q06287, ECO:0000269|PubMed:20047967}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:11935223}. |
Top Pathways | Ribosome biogenesis in eukaryotes |
Human EMG1 full length protein - ab130059 from Abcam
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EMG1 / NEP1 Antibody Blocking Peptide - LS-E775 from LifeSpan Bioscience
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EMG1 / NEP1 Antibody Blocking Peptide - LS-E14868 from LifeSpan Bioscience
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Recombinant Human EMG1 Protein - NBP1-98914 from Novus Biologicals
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EMG1-Antibody-Center-Blocking-peptide - BP11129c from Abgent, a WuXi AppTec company
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Human EMG1 protein - orb168290 from Biorbyt
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EMG1 Blocking Peptide - 33R-8582 from Fitzgerald
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EMG1 protein (His tag) - 80R-2360 from Fitzgerald
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EMG1 / C2F (1-244, His-tag) - AR50441PU-N from Acris Antibodies
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EMG1 / C2F (1-244, His-tag) - AR50441PU-S from Acris Antibodies
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EMG1 / C2F - P5850 from Acris Antibodies
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EMG1, 1-244aa, Human, His tag, E.coli - 01-P1617 from ARP American Research Products
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EMG1 fusion protein - Ag2575 from Proteintech Group
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EMG1 Human - PRPS-1129 from NeoScientific
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Recombinant Human EMG1 Nucleolar Protein - BP002886-PRO-1122 from Syd Labs
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EMG1, 1-244aa, Recombinant Protein - GWB-P0421E from Genway Biotech
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Recombinant Human EMG1 Nucleolar Protein Homolog(S. cerevisiae), His-tagged - EMG1-6938H from Creative Biomart
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Recombinant Human Ribosomal RNA small subunit methyltransferase NEP1(EMG1) - CSB-YP852924HU CSB-EP852924HU CSB-BP852924HU CSB-MP852924HU from Cusabio
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EMG1, 1-244aa, Human, His tag, E.coli - ATGP1617 from ATGen
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EMG1 / C2F - TP308885 from Acris Antibodies
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EMG1 Peptide, Human - M34GP04903H from Creative Peptides
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EMG1 - PAT-81657-1 from Nordic BioSite
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EMG1 - PAT-81657-2 from Nordic BioSite
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EMG1 Recombinant Protein Antigen - NBP2-54688PEP from Novus Biologicals
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EMG1 Recombinant Protein Antigen - NBP2-55324PEP from Novus Biologicals
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