| Gene Symbol |
DZIP3
|
| Entrez Gene |
9666
|
| Alt Symbol |
PPP1R66, UURF2, hRUL138
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DAZ interacting zinc finger protein 3
|
| Other Description |
DAZ interacting protein 3, zinc finger|DAZ-interacting protein 3|E3 ubiquitin-protein ligase DZIP3|RNA-binding ubiquitin ligase of 138 kDa|UURF2 ubiquitin ligase|human RNA-binding ubiquitin ligase of 138 kDa|protein phosphatase 1, regulatory subunit 66|zinc finger DAZ interacting protein 3
|
| Swissprots |
Q86Y13 Q86Y14 Q6P3R9 Q86Y15 Q86Y16 Q8IWI0 B3KN01 O75162 Q96RS9 Q6PH82
|
| Accessions |
CAE91651 CAH05532 EAW79721 EAW79722 Q86Y13 AB014575 BAA31650 AF279370 AAK69484 AK023138 BAG51163 AK023389 AK294967 BAG58040 AK297451 BAG59875 AK303942 BAG64870 AY227651 AAO72967 AY227652 AAO72968 AY227653 AAO72969 AY227654 AAO72970 AY495710 AAS75122 BC012631 BC039018 AAH39018 BC056674 AAH56674 BC063882 AAH63882 BX495180 DA494378 GQ129281 ACT64415 GQ129282 ACT64416 HQ258001 ADR82755 XM_005247914 XP_005247971 XM_005247915 XP_005247972 XM_005247916 XP_005247973 XM_005247917 XP_005247974 XM_005247918 XP_005247975 XM_005247919 XP_005247976 XM_011513336 XP_011511638 XR_924222 NM_014648 NP_055463
|
| Function |
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. {ECO:0000269|PubMed:12538761}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12538761}.
|
| Tissue Specificity |
Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas. {ECO:0000269|PubMed:12538761}.
|
![Western Blot: DZIP3 Overexpression Lysate (Adult Normal) [NBL1-10083] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DZIP3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4585_DZIP3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10083-img0002.jpg)