| Gene Symbol |
Pde4d
|
| Entrez Gene |
24627
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 4D, cAMP-specific
|
| Other Description |
DPDE3|Phosphodiesterase 4D cAMP-specific (dunce|Phosphodiesterase 4D, cAMP-specific (dunce|cAMP-specific 3',5'-cyclic phosphodiesterase 4D|cAMP-specific phosphodiesterase PDE4D|cAMP-specific phosphodiesterase splice variant PDE4D8|phosphodiesterase 4D, cAMP specific|phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
|
| Swissprots |
Q6TRI0 O35470 F1M1H7 Q8CG04 P14270 Q8CG06 A1E347 A1EC59
|
| Accessions |
AAA18924 AAA18925 EDM10316 EDM10319 EDM10322 EDM10323 EDM10325 EDM10327 P14270 AF031373 AAB95266 AF536974 AAN10116 AF536979 AAN10121 AY388961 AAQ90405 EF102484 ABK97408 EF121818 ABL14108 L27059 AAA56857 L27060 AAC26969 U09455 AAA20401 U09456 AAA20393 U09457 AAB81869 XM_008760721 XP_008758943 XM_008760722 XP_008758944 XM_008760723 XP_008758945 NM_017032 NP_058728 NM_001113328 NP_001106799 NM_001113329 NP_001106800 NM_001113332 NP_001106803 NM_001113334 NP_001106805
|
| Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
|
| Subcellular Location |
Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
|
| Tissue Specificity |
Expressed in epithelial cells. Isoform 33, isoform 4, isoform 5 and isoform 9 are expressed in brain. Isoform 33, isoform 5, isoform 8 and isoform 9 are expressed in heart (at protein level). Isoform 4 and isoform 6 are strongly expressed in cortex and cerebellum. Isoform 7 is strongly expressed in cortex and testis; weakly expressed in kidney, lung, spleen and cerebellum. Isoform 8 is strongly expressed in lung, heart and liver. Isoform 31, isoform 32, isoform 33, isoform 5 and isoform 9 are widely distributed. {ECO:0000269|PubMed:17244609, ECO:0000269|PubMed:17261351}.
|
| Top Pathways |
Morphine addiction, cAMP signaling pathway, Purine metabolism
|