| Gene Symbol |
Nfatc1
|
| Entrez Gene |
18018
|
| Alt Symbol |
2210017P03Rik, AI449492, AV076380, NF-ATc, NFAT2, NFATc, Nfatcb
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
|
| Other Description |
NF-ATc1|NFAT transcription complex cytosolic component|nuclear factor of activated T-cells, cytoplasmic 1|nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1|transcription factor NF-ATc
|
| Swissprots |
O88942 O70345
|
| Accessions |
AAL96484 EDL09401 O88942 AF049606 AAC05505 AF087434 AAC36725 AF239169 AAF40225 AI449492 AK004810 BAB23581 AK008747 AK048610 AK144965 BAE26158 BB647702 BC061509 AAH61509 EU887567 ACG55587 EU887568 ACG55588 EU887569 ACG55589 EU887570 ACG55590 EU887571 ACG55591 EU887572 ACG55592 NM_001164109 NP_001157581 NM_001164110 NP_001157582 NM_001164111 NP_001157583 NM_001164112 NP_001157584 NM_016791 NP_058071 NM_198429 NP_940821
|
| Function |
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin- mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in spleen, lung, skeletal muscle, thymus and skin. Weakly expressed in heart, brain, liver and kidney. Not expressed in testis.
|
| Top Pathways |
Osteoclast differentiation, Wnt signaling pathway, HTLV-I infection, MAPK signaling pathway, Oxytocin signaling pathway
|