ENPP1

Gene Symbol	ENPP1
Entrez Gene	5167
Alt Symbol	ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1
Species	Human
Gene Type	protein-coding
Description	ectonucleotide pyrophosphatase/phosphodiesterase 1
Other Description	E-NPP 1|Ly-41 antigen|alkaline phosphodiesterase 1|ectonucleotide pyrophosphatase/phosphodiesterase family member 1|membrane component chromosome 6 surface marker 1|membrane component, chromosome 6, surface marker 1|phosphodiesterase I/nucleotide pyrophosphatase 1|plasma-cell membrane glycoprotein 1|plasma-cell membrane glycoprotein PC-1
Swissprots	Q9NPZ3 Q5T9R6 Q9Y6K3 Q9P1P6 P22413 Q9UP61
Accessions	AAD38420 AAD38421 AAF36094 BAA97562 CAC39442 EAW48041 EAW48042 P22413 AK314870 BAG37385 BC033008 BC059375 AAH59375 BX537580 CAD97789 D12485 BAA02054 M57736 AAA63237 XM_011535896 XP_011534198 NM_006208 NP_006199
Function	By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function. {ECO:0000269|PubMed:10615944, ECO:0000269|PubMed:8001561}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein. Basolateral cell membrane; Single-pass type II membrane protein. Secreted {ECO:0000250}. Note=The proteolytically processed form is secreted (By similarity). Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts. In bile duct cells and cancer cells, located to the apical cytoplasmic side. {ECO:0000250}.
Tissue Specificity	Expressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis. {ECO:0000269|PubMed:9344668}.
Top Pathways	Purine metabolism, Nicotinate and nicotinamide metabolism, Riboflavin metabolism, Pantothenate and CoA biosynthesis, Starch and sucrose metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ENPP1 peptide - ab45822 from Abcam Category Peptide Prices $290.00 Sizes 100 µg Species Human

Human ENPP1 full length protein - ab159083 from Abcam Category Protein Source Wheat germ Species Human

Human ENPP1 protein fragment - ab167943 from Abcam Category Protein Source HEK 293 cells Species Human

Human ENPP1 protein fragment - ab159084 from Abcam Category Protein Source Wheat germ Species Human

ENPP1 Antibody Blocking Peptide - LS-E25960 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ENPP-1 Blocking Peptide - NB600-816PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 100 µg Species Human

Recombinant Human ENPP-1 Protein - H00005167-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human ENPP-1 Protein - H00005167-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ENPP-1 Protein - H00005167-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

ENPP1 blocking peptide - GTX89508-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Recombinant Human ENPP-1, CF - 6136-EN-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human ENPP1 protein - orb191426 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source HEK 293. Species Human

Human ENPP1 Protein - abx066382 from Abbexa Category Protein Source E.coli Species Human

Human ENPP1 Protein - abx066381 from Abbexa Category Protein Source E.coli Species Human

ENPP1 Peptide - AC21-0787-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ENPP1 - H00005167-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

ENPP1 - H00005167-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

ENPP1 - H00005167-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ENPP1 - H00005167-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

ENPP1 - H00005167-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ENPP1 - H00005167-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1), Human - 20-9042 from ARP American Research Products Category Protein Prices $565.00 Sizes 50 µg Source E.coli Species Human

Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1), Human - 20-9043 from ARP American Research Products Category Protein Prices $565.00 Sizes 50 µg Source E.coli Species Human

ENPP1 Peptide - 45-538P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

ENPP1 fusion protein - ag6019 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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