| Gene Symbol |
PSCA
|
| Entrez Gene |
8000
|
| Alt Symbol |
PRO232
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostate stem cell antigen
|
| Other Description |
-
|
| Swissprots |
O43653 Q6UW92
|
| Accessions |
CAL69804 CDH61610 CDH92562 EAW82312 EAW82313 O43653 AF043498 AAC39607 AI685668 AJ297436 CAB97347 AY358912 AAQ89271 BC023582 AAH23582 BC048808 BC065183 AAH65183 BI758811 BM768967 BU157227 CB993163 HQ447653 ADQ32138 NM_005672 NP_005663 NR_033343
|
| Function |
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. {ECO:0000269|PubMed:18488030}.
|
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor.
|
| Tissue Specificity |
Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen- independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). {ECO:0000269|PubMed:10713670, ECO:0000269|PubMed:18488030}.
|
![Western Blot: PSCA Overexpression Lysate (Adult Normal) [NBL1-14856] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PSCA.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1034_PSCA%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14856-img0002.jpg)