| Gene Symbol | TNIP1 |
|---|---|
| Entrez Gene | 10318 |
| Alt Symbol | ABIN-1, NAF1, VAN, nip40-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TNFAIP3 interacting protein 1 |
| Other Description | A20-binding inhibitor of NF-kappa-B activation 1|HIV-1 Nef-interacting protein|Nef-associated factor 1 SNP|TNFAIP3-interacting protein 1|virion-associated nuclear shuttling protein |
| Swissprots | E7ET96 Q05KP4 E7EPY1 Q15025 Q9H1J3 A4F1W8 Q6N077 A4F1X2 A4F1X4 Q05KP3 Q96EL9 A4F1W9 Q99833 A4F1X7 A4F1X6 A4F1X9 A4F1X5 B7Z699 O76008 |
| Accessions | EAW61688 EAW61689 EAW61690 EAW61691 Q15025 AB177543 BAF34946 AB177544 BAF34947 AB252970 BAF48787 AB252971 BAF48788 AB252972 BAF48789 AB252973 BAF48790 AB252974 BAF48791 AB252975 BAF48792 AB252976 BAF48793 AB252977 BAF48794 AB252978 BAF48795 AB252979 BAF48796 AB252980 BAF48797 AB252981 BAF48798 AB252982 BAF48799 AJ011895 CAA09855 AJ011896 CAA09856 AK074400 AK097213 AK290999 BAF83688 AK298685 BAH12846 AK299975 BAH13185 AK303573 BAH13988 AW589284 AW612566 AY012155 AAG42154 BC007666 BC012133 AAH12133 BC014008 AAH14008 BP254790 BX640647 CAE45793 D30755 BAA06416 DA643531 DA752275 DA810872 DC374977 DQ893467 ABM84393 DQ896340 ABM87339 U39403 AAC99999 U83844 AAB41438 XM_005268355 XP_005268412 XM_006714751 XP_006714814 XM_006714752 XP_006714815 XM_011537538 XP_011535840 NM_001252385 NP_001239314 NM_001252386 NP_001239315 NM_001252390 NP_001239319 NM_001252391 NP_001239320 NM_001252392 NP_001239321 NM_001252393 NP_001239322 NM_001258454 NP_001245383 NM_001258455 NP_001245384 NM_001258456 NP_001245385 NM_006058 NP_006049 |
| Function | Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti- inflammatory response of macrophages and positively regulates TLR- induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export o |
| Subcellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. |
| Tissue Specificity | Ubiquitous. Strongly expressed in peripheral blood lymphocytes, spleen and skeletal muscle, and is weakly expressed in the brain. In peripheral blood mononucleocytes, isoform 4 is mainly expressed and isoform 1 and isoform 7 are almost not expressed. Expression of isoform 1 and isoform 7 increases in leukemic cells. {ECO:0000269|PubMed:17016622}. |