| Gene Symbol |
Tspo
|
| Entrez Gene |
12257
|
| Alt Symbol |
Bzrp, IBP, PBR, Tspo1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
translocator protein
|
| Other Description |
PKBS|benzodiazepine receptor, peripheral|isoquinoline-binding protein|mitochondrial benzodiazepine receptor|peripheral-type benzodiazepine receptor
|
| Swissprots |
P50637 Q62118 Q6LCZ0
|
| Accessions |
AAA83253 AAL87529 AAL87530 EDL04468 P50637 AA472650 AI841615 AK149743 BAE29056 AK150516 BAE29628 AK151421 BAE30386 AK151569 BAE30511 AK151824 BAE30721 AK152082 BAE30932 AK152827 BAE31528 AK152860 AK153159 BAE31769 AK153273 BAE31860 AK156489 BAE33730 AK165450 BAE38192 AK165822 BAE38396 AK166125 BAE38585 AK172384 BAE42976 AK185664 AK208413 AK209430 AK215755 BC002055 AAH02055 D21207 BAA04749 L17306 AAA20127 NM_009775 NP_033905
|
| Function |
Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060). {ECO:0000250, ECO:0000269|PubMed:24174323, ECO:0000269|PubMed:24814875, ECO:0000269|PubMed:24936060, ECO:0000269|PubMed:8114671, ECO:0000269|PubMed:9832438}.
|
| Subcellular Location |
Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Detected in liver (at protein level). Ubiquitous. {ECO:0000269|PubMed:24174323, ECO:0000269|PubMed:24936060}.
|
| Top Pathways |
HTLV-I infection, Neuroactive ligand-receptor interaction
|