ADGRG1
| Gene Symbol | ADGRG1 |
|---|---|
| Entrez Gene | 9289 |
| Alt Symbol | BFPP, BPPR, GPR56, TM7LN4, TM7XN1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adhesion G protein-coupled receptor G1 |
| Other Description | 7-transmembrane protein with no EGF-like N-terminal domains-1|G protein-coupled receptor 56|G-protein coupled receptor 56 |
| Swissprots | Q6ZMP1 A6NIT7 O95966 B0M0K4 Q8NGB3 Q9Y653 Q96HB4 B4DR54 A6NJV9 |
| Accessions | BAC06124 CAD70079 EAW82939 EAW82940 EAW82941 EAW82942 EAW82943 EAW82944 EAW82945 Q9Y653 AF106858 AAD30545 AJ011001 CAB37294 AK074399 AK075270 BAG52099 AK075555 BAG52166 AK131550 BAD18684 AK297236 BAG59718 AK299110 BAG61166 AK311156 AK312405 AL137591 AY358400 AAQ88766 BC008770 AAH08770 BC013207 BE893273 BT007311 AAP35975 CR936747 DA153038 DA225816 DA245676 DA386131 DB231209 DB567419 DC369393 EU432119 ABY87918 XM_005256237 XP_005256294 XM_005256238 XP_005256295 XM_005256239 XP_005256296 XM_005256240 XP_005256297 XM_005256241 XP_005256298 XM_005256242 XP_005256299 XM_005256244 XP_005256301 XM_005256245 XP_005256302 XM_005256246 XP_005256303 XM_005256247 XP_005256304 XM_005256248 XP_005256305 XM_005256249 XP_005256306 XM_005256251 XP_005256308 XM_005256252 XP_005256309 XM_005256254 XP_005256311 XM_005256255 XP_005256312 XM_006721338 XP_006721401 XM_006721339 XP_006721402 XM_006721340 XP_006721403 XM_006721341 XP_006721404 XM_006721342 XP_006721405 XM_006721343 XP_006721406 XM_006721344 XP_006721407 XM_006721345 XP_006721408 XM_006721346 XP_006721409 XM_006721347 XP_006721410 XM_011523461 XP_011521763 XM_011523462 XP_011521764 XM_011523463 XP_011521765 XM_011523464 XP_011521766 XM_011523465 XP_011521767 XM_011523466 XP_011521768 XM_011523467 XP_011521769 XM_011523468 XP_011521770 NM_001145770 NP_001139242 NM_001145771 NP_001139243 NM_001145772 NP_001139244 NM_001145773 NP_001139245 NM_001145774 NP_001139246 NM_001290142 NP_001277071 NM_001290143 NP_001277072 NM_001290144 NP_001277073 NM_005682 NP_005673 NM_201524 NP_958932 NM_201525 NP_958933 |
| Function | Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis. Required for normal cortical development and regulation of neuroprogenitor cells proliferation. {ECO:0000269|PubMed:16757564, ECO:0000269|PubMed:19572147, ECO:0000269|PubMed:217089 |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:21349848}; Multi-pass membrane protein {ECO:0000269|PubMed:21349848}. |
| Tissue Specificity | Widely distributed with highest levels found in thyroid gland, brain and heart. Expressed in a great number of tumor cells. Expression is down-regulated in different tumors from highly metastatic cells. {ECO:0000269|PubMed:16757564}. |
GPR56 CRISPR/Cas9 KO Plasmid (h) - sc-406370 from Santa Cruz Biotechnology
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GPR56 HDR Plasmid (h) - sc-406370-HDR from Santa Cruz Biotechnology
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GPR56 Double Nickase Plasmid (h) - sc-406370-NIC from Santa Cruz Biotechnology
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GPR56 Double Nickase Plasmid (h2) - sc-406370-NIC-2 from Santa Cruz Biotechnology
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GPR56 CRISPR Activation Plasmid (h) - sc-406370-ACT from Santa Cruz Biotechnology
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GPR56 CRISPR Activation Plasmid (h2) - sc-406370-ACT-2 from Santa Cruz Biotechnology
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GPR56 Lentiviral Activation Particles (h) - sc-406370-LAC from Santa Cruz Biotechnology
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GPR56 Lentiviral Activation Particles (h2) - sc-406370-LAC-2 from Santa Cruz Biotechnology
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GPR56 siRNA (h) - sc-60749 from Santa Cruz Biotechnology
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GPR56 shRNA Plasmid (h) - sc-60749-SH from Santa Cruz Biotechnology
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GPR56 shRNA (h) Lentiviral Particles - sc-60749-V from Santa Cruz Biotechnology
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GPR56 RNAi - H00009289-R04 from Novus Biologicals
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GPR56 RNAi - H00009289-R06 from Novus Biologicals
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GPR56 RNAi - H00009289-R05 from Novus Biologicals
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MISSION® esiRNA - EHU102491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9608 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9608 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09365 from Sigma-Aldrich
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GPR56 siRNA (Human) - CRH6149 from Cohesion Biosciences
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GPR56 - MBS8238398 from MyBioSource
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shRNA set against Human GPR56 (NM_005682.5) - SHH306918 from Creative biogene
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Human GPR56 siRNA - orb266651 from Biorbyt
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GPR56 shRNA Plasmid (Human) - CHH6149 from Cohesion Biosciences
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GPR56 miRNA 3'UTR clone - MiUTR3H-06551 from Creative biogene
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GPR56 miRNA 3'UTR clone - MiUTR3H-06552 from Creative biogene
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