| Gene Symbol |
MARK2
|
| Entrez Gene |
2011
|
| Alt Symbol |
EMK-1, EMK1, PAR-1, Par-1b, Par1b
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAP/microtubule affinity-regulating kinase 2
|
| Other Description |
ELKL motif kinase 1|PAR1 homolog b|Ser/Thr protein kinase PAR-1B|serine/threonine protein kinase EMK|serine/threonine-protein kinase MARK2
|
| Swissprots |
Q7KZI7 Q5XGA3 Q15524 Q96RG0 Q15449 Q68A18 Q96HB3
|
| Accessions |
EAW74174 EAW74175 EAW74176 EAW74177 EAW74178 EAW74179 EAW74180 Q7KZI7 AB188493 BAD37141 AB271694 BAF96440 AF387638 AAK82368 AI524222 AK225766 AK290339 BAF83028 AK307858 AY562187 AAT67601 AY562188 AAT67602 BC008771 AAH08771 BC084540 AAH84540 BM719402 BM724555 BT007342 AAP36006 BX383836 DA855402 DQ578603 DQ890693 ABM81619 DQ893876 ABM84802 X97630 CAA66229 Z25427 CAA80914 XM_011544789 XP_011543091 XM_011544790 XP_011543092 XM_011544791 XP_011543093 XM_011544792 XP_011543094 XM_011544793 XP_011543095 XM_011544794 XP_011543096 XM_011544795 XP_011543097 XM_011544796 XP_011543098 XM_011544797 XP_011543099 XM_011544798 XP_011543100 XR_949801 XR_949802 NM_001039469 NP_001034558 NM_001163296 NP_001156768 NM_001163297 NP_001156769 NM_004954 NP_004945 NM_017490 NP_059672
|
| Function |
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule- dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDA
|
| Subcellular Location |
Cell membrane; Peripheral membrane protein. Cytoplasm. Lateral cell membrane. Cytoplasm, cytoskeleton. Note=Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.
|
| Tissue Specificity |
High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney. {ECO:0000269|PubMed:9730619}.
|