| Gene Symbol | EIF3L |
|---|---|
| Entrez Gene | 51386 |
| Alt Symbol | EIF3EIP, EIF3S11, EIF3S6IP, HSPC021, HSPC025, MSTP005 |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 3, subunit L |
| Other Description | eIEF associated protein HSPC021|eukaryotic translation initiation factor 3 subunit 6-interacting protein|eukaryotic translation initiation factor 3 subunit E-interacting protein|eukaryotic translation initiation factor 3 subunit L |
| Swissprots | Q5TI15 Q6ICD2 Q53HT4 B4DYB2 Q5QTR1 B2RDG6 G8JLH4 Q9Y262 Q53HQ1 |
| Accessions | EAW60195 EAW60196 EAW60197 EAW60198 Q9Y262 AF077207 AAD27002 AF083243 AAD39841 AF109359 AAQ13507 AK027429 BAG51322 AK056129 BAG51631 AK093540 BAG52737 AK098457 BAC05310 AK098713 AK129648 AK222496 BAD96216 AK222529 BAD96249 AK293629 BAG57085 AK298776 BAG60918 AK301323 BAG62872 AK302346 BAG63674 AK315533 BAG37913 AL357455 BC001101 AAH01101 BC007510 AAH07510 BC011448 AAH11448 BC029265 AAH29265 CD638692 CR456436 CAG30322 CU013035 CAK54466 CU013323 CAK54765 DA051005 DA663575 DQ891842 ABM82768 DQ893595 ABM84521 DQ895030 ABM85956 EU176311 ABW03762 XM_005261625 XP_005261682 XM_006724260 XP_006724323 NM_001242923 NP_001229852 NM_016091 NP_057175 |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}. |