Gene Symbol | TKFC |
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Entrez Gene | 26007 |
Alt Symbol | DAK, NET45 |
Species | Human |
Gene Type | protein-coding |
Description | triokinase/FMN cyclase |
Other Description | ATP-dependent dihydroxyacetone kinase|DHA kinase|Dha kinase/FMN cyclase|FAD-AMP lyase cyclic FMN forming|FAD-AMP lyase cyclizing|bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)|dihydroxyacetone kinase 2 homolog|glycerone kinase |
Swissprots | Q9H895 Q2L9C1 Q3LXA3 Q9BVA7 Q53EQ9 |
Accessions | CBF62860 CBU87736 EAW73938 EAW73939 EAW73940 Q3LXA3 AK023915 BAB14722 AK094516 AK223580 BAD97300 AK308553 AL110260 CAB53701 BC001341 AAH01341 BC120929 AAI20930 BF197629 DA932478 DB056724 DQ138290 ABA10576 DQ344550 ABC70184 XM_011544910 XP_011543212 XM_011544911 XP_011543213 XM_011544912 XP_011543214 XM_011544913 XP_011543215 XM_011544914 XP_011543216 XM_011544915 XP_011543217 XM_011544916 XP_011543218 XM_011544917 XP_011543219 XM_011544918 XP_011543220 XM_011544919 XP_011543221 XM_011544920 XP_011543222 XM_011544921 XP_011543223 XM_011544922 XP_011543224 XM_011544923 XP_011543225 NM_015533 NP_056348 |
Function | Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. {ECO:0000269|PubMed:16289032, ECO:0000269|PubMed:4688871}. |
Tissue Specificity | Detected in erythrocytes (at protein level). {ECO:0000269|PubMed:4688871}. |
Top Pathways | RIG-I-like receptor signaling pathway, Glycerolipid metabolism, Carbon metabolism |
DAK CRISPR/Cas9 KO Plasmid (h) - sc-408850 from Santa Cruz Biotechnology
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DAK HDR Plasmid (h) - sc-408850-HDR from Santa Cruz Biotechnology
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DAK Double Nickase Plasmid (h) - sc-408850-NIC from Santa Cruz Biotechnology
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DAK Double Nickase Plasmid (h2) - sc-408850-NIC-2 from Santa Cruz Biotechnology
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DAK CRISPR Activation Plasmid (h) - sc-408850-ACT from Santa Cruz Biotechnology
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DAK CRISPR Activation Plasmid (h2) - sc-408850-ACT-2 from Santa Cruz Biotechnology
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DAK Lentiviral Activation Particles (h) - sc-408850-LAC from Santa Cruz Biotechnology
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DAK Lentiviral Activation Particles (h2) - sc-408850-LAC-2 from Santa Cruz Biotechnology
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DAK siRNA (h) - sc-97079 from Santa Cruz Biotechnology
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DAK shRNA Plasmid (h) - sc-97079-SH from Santa Cruz Biotechnology
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DAK shRNA (h) Lentiviral Particles - sc-97079-V from Santa Cruz Biotechnology
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DAK RNAi - H00026007-R02 from Novus Biologicals
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MISSION® esiRNA - EHU090671 from Sigma-Aldrich
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MISSION® siRNA - SIHK0537 from Sigma-Aldrich
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MISSION® siRNA - SIHK0536 from Sigma-Aldrich
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MISSION® siRNA - SIHK0535 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6921 from Sigma-Aldrich
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DAK siRNA (Human) - CRH8648 from Cohesion Biosciences
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DAK - MBS828743 from MyBioSource
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shRNA set against Human DAK (NM_015533.3) - SHH274461 from Creative biogene
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shRNA set against Human DAK(NM_015533.3) - SHG221131 from Creative biogene
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DAK shRNA Plasmid (Human) - CHH8648 from Cohesion Biosciences
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DAK miRNA 3'UTR clone - MiUTR1H-02659 from Creative biogene
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