| Gene Symbol |
RBM19
|
| Entrez Gene |
9904
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA binding motif protein 19
|
| Other Description |
RNA-binding motif protein 19|probable RNA-binding protein 19
|
| Swissprots |
Q9UFN5 A8K5X9 Q9BPY6 Q9Y4C8
|
| Accessions |
EAW98062 EAW98063 Q9Y4C8 AA594568 AB014582 BAA31657 AI218902 AK291444 BAF84133 AK314606 BAG37176 AL117547 CAB55987 BC004289 AAH04289 BC006137 AAH06137 DB096676 EU831458 ACE87145 EU831545 ACE86464 XM_011539038 XP_011537340 XR_944848 NM_001146698 NP_001140170 NM_001146699 NP_001140171 NM_016196 NP_057280
|
| Function |
Plays a role in embryo pre-implantation development. {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16027046}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level). {ECO:0000269|PubMed:16027046}.
|
