| Gene Symbol | AIR1 |
|---|---|
| Entrez Gene | 854731 |
| Alt Symbol | - |
| Species | Yeast |
| Gene Type | protein-coding |
| Description | Air1p |
| Other Description | - |
| Swissprots | P40507 D6VVK5 |
| Accessions | DAA08471 P40507 NM_001179429 NP_012186 |
| Function | Component of the TRAMP (TRF4) and TRAMP5 complexes which have a poly(A) RNA polymerase activity and are involved in a post- transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Both complexes polyadenylate RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. AIR1 also inhibits the methylation of NPL3 mediated by HMT1 through its interaction with HMT1. {ECO:0000269|PubMed:10896665, ECO:0000269|PubMed:15828860, ECO:0000269|PubMed:15935759, ECO:0000269|PubMed:16374505}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. |
| Top Pathways | RNA degradation |
Recombinant Saccharomyces cerevisiae Protein AIR1(AIR1) - CSB-YP331183SVG CSB-EP331183SVG CSB-BP331183SVG CSB-MP331183SVG from Cusabio
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Protein AIR1 (AIR1), Recombinant Protein - MBS1134203 from MyBioSource
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