| Gene Symbol |
TAF1C
|
| Entrez Gene |
9013
|
| Alt Symbol |
MGC:39976, SL1, TAFI110, TAFI95
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
|
| Other Description |
RNA polymerase I-specific TBP-associated factor 110 kDa|SL1, 110kD subunit|TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD|TATA box-binding protein-associated factor 1C|TATA box-binding protein-associated factor RNA polymerase I subunit C|TBP-associated factor 1C|transcription factor SL1|transcription initiation factor SL1/TIF-IB subunit C
|
| Swissprots |
Q8N6V3 B7Z5S4 B7Z5K5 Q59F67 B7Z9L7 B7Z908 Q15572
|
| Accessions |
AAN38818 CBX47548 CBX47549 EAW95495 EAW95496 EAW95497 EAW95498 EAW95499 Q15572 AB209594 BAD92831 AK097031 BAG53410 AK299060 BAH12941 AK299347 BAH13010 AK304261 BAH14144 AK304739 BAH14248 AK315982 BAH14353 AU130229 BC028131 AAH28131 CA397963 DC376588 DC377529 JF432485 ADZ15702 L39059 AAA62861 XM_005256226 XP_005256283 XM_005256227 XP_005256284 XM_006721325 XP_006721388 XM_006721326 XP_006721389 XM_011523432 XP_011521734 NM_001243156 NP_001230085 NM_001243157 NP_001230086 NM_001243158 NP_001230087 NM_001243159 NP_001230088 NM_001243160 NP_001230089 NM_005679 NP_005670 NM_139353 NP_647610
|
| Function |
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. {ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:15970593}.
|
| Subcellular Location |
Nucleus.
|