| Gene Symbol | Il11ra1 |
|---|---|
| Entrez Gene | 16157 |
| Alt Symbol | AI314697, GP130, Il-11ra, Il11ra, Il11ra2, NR1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interleukin 11 receptor, alpha chain 1 |
| Other Description | IL-11 receptor subunit alpha-1|IL-11R subunit alpha-1|IL-11R-alpha-1|IL-11RA1|Il-11ra-alpha|NR-1|enhancer trap locus homolog 2|etl-2|interleukin 11 receptor, alpha chain 2|interleukin-11 receptor subunit alpha-1|locus 2|novel cytokine receptor 1 |
| Swissprots | A2AMS4 Q6NSQ0 Q64385 |
| Accessions | CAA63873 Q64385 AK143811 AK146742 BAE27402 AK155407 BAE33248 AK159559 AK187457 AK202561 BC004619 AAH04619 BC057664 AAH57664 BC069984 AAH69984 BY149476 BY777524 U14412 AAA53248 X74953 CAA52908 NM_001163401 NP_001156873 NM_001172054 NP_001165525 NM_010549 NP_034679 |
| Function | Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo. {ECO:0000269|PubMed:8662802}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage |