Gene Symbol | Il11ra1 |
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Entrez Gene | 16157 |
Alt Symbol | AI314697, GP130, Il-11ra, Il11ra, Il11ra2, NR1 |
Species | Mouse |
Gene Type | protein-coding |
Description | interleukin 11 receptor, alpha chain 1 |
Other Description | IL-11 receptor subunit alpha-1|IL-11R subunit alpha-1|IL-11R-alpha-1|IL-11RA1|Il-11ra-alpha|NR-1|enhancer trap locus homolog 2|etl-2|interleukin 11 receptor, alpha chain 2|interleukin-11 receptor subunit alpha-1|locus 2|novel cytokine receptor 1 |
Swissprots | A2AMS4 Q6NSQ0 Q64385 |
Accessions | CAA63873 Q64385 AK143811 AK146742 BAE27402 AK155407 BAE33248 AK159559 AK187457 AK202561 BC004619 AAH04619 BC057664 AAH57664 BC069984 AAH69984 BY149476 BY777524 U14412 AAA53248 X74953 CAA52908 NM_001163401 NP_001156873 NM_001172054 NP_001165525 NM_010549 NP_034679 |
Function | Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo. {ECO:0000269|PubMed:8662802}. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage |
IL-11Rα1 CRISPR/Cas9 KO Plasmid (m) - sc-421080 from Santa Cruz Biotechnology
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IL-11Rα1 HDR Plasmid (m) - sc-421080-HDR from Santa Cruz Biotechnology
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IL-11Rα1 Double Nickase Plasmid (m) - sc-421080-NIC from Santa Cruz Biotechnology
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IL-11Rα1 Double Nickase Plasmid (m2) - sc-421080-NIC-2 from Santa Cruz Biotechnology
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IL-11Rα1 CRISPR Activation Plasmid (m) - sc-421080-ACT from Santa Cruz Biotechnology
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IL-11Rα1 CRISPR Activation Plasmid (m2) - sc-421080-ACT-2 from Santa Cruz Biotechnology
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IL-11Rα1 Lentiviral Activation Particles (m) - sc-421080-LAC from Santa Cruz Biotechnology
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IL-11Rα1 Lentiviral Activation Particles (m2) - sc-421080-LAC-2 from Santa Cruz Biotechnology
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IL-11Rα siRNA (m) - sc-35648 from Santa Cruz Biotechnology
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IL-11Rα shRNA Plasmid (m) - sc-35648-SH from Santa Cruz Biotechnology
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IL-11Rα shRNA (m) Lentiviral Particles - sc-35648-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU170761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33731 from Sigma-Aldrich
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IL11RA1 siRNA (Mouse) - CRM2033 from Cohesion Biosciences
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IL11RA1 - MBS8216738 from MyBioSource
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Mouse IL11RA1 siRNA - orb281509 from Biorbyt
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IL11RA1 shRNA Plasmid (Mouse) - CHM2033 from Cohesion Biosciences
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