| Gene Symbol |
Cited4
|
| Entrez Gene |
56222
|
| Alt Symbol |
MRG-2, Mrg2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
|
| Other Description |
cbp/p300-interacting transactivator 4|cited4|msg1-related protein 2
|
| Swissprots |
Q9CZV4 Q8R176 Q66JX0 Q9WUL8
|
| Accessions |
EDL30419 EDL30420 Q9WUL8 AF143369 AAD37357 AK012136 BAB28054 AK154030 BAE32327 BC025116 AAH25116 BC080723 AAH80723 BC132360 AAI32361 BC132362 AAI32363 NM_019563 NP_062509
|
| Function |
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. {ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:12504852}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:Q96RK1}.
|
| Tissue Specificity |
Strongly expressed in heart, spleen and testis, and weakly in liver and kidney. {ECO:0000269|PubMed:12504852}.
|