| Gene Symbol |
MBOAT7
|
| Entrez Gene |
79143
|
| Alt Symbol |
BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane bound O-acyltransferase domain containing 7
|
| Other Description |
1-acylglycerophosphatidylinositol O-acyltransferase|LPLAT 7|bladder and breast carcinoma-overexpressed gene 1 protein|h-mboa-7|leukocyte receptor cluster (LRC) member 4|lyso-PI acyltransferase|lysophosphatidylinositol acyltransferase|lysophospholipid acyltransferase 7|malignant cell expression-enhanced gene/tumor progression-enhanced
|
| Swissprots |
B4DQ87 Q9BRE9 B0V3I5 Q7L5N2 Q96N66 Q9BPV2 Q99908 A9C4B6 Q05DF0
|
| Accessions |
EAW72199 EAW72200 EAW72201 EAW72202 Q96N66 AF211969 AI032483 AK055908 BAB71043 AK122789 AK123290 AK293199 BAG56739 AK298689 BAG60849 AK311493 AW014416 BC002512 AAH02512 BC003164 AAH03164 BC006309 AAH06309 BC015857 AAH15857 BQ045276 BU633996 CB240899 DA338950 EU016381 ABV66273 JF432451 ADZ15668 S82470 AAB37433 XM_011527299 XP_011525601 XM_011527300 XP_011525602 XM_011547124 XP_011545426 XM_011547534 XP_011545836 XM_011547796 XP_011546098 XM_011547992 XP_011546294 XM_011548171 XP_011546473 XM_011548363 XP_011546665 XM_011548570 XP_011546872 XM_011548628 XP_011546930 XM_011548717 XP_011547019 NM_001146056 NP_001139528 NM_001146082 NP_001139554 NM_001146083 NP_001139555 NM_024298 NP_077274
|
| Function |
Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3- phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18094042, ECO:0000269|PubMed:18772128}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium. {ECO:0000269|PubMed:18772128}.
|
| Top Pathways |
Glycerophospholipid metabolism
|