| Gene Symbol |
Usp22
|
| Entrez Gene |
216825
|
| Alt Symbol |
AI427806
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 22
|
| Other Description |
deubiquitinating enzyme 22|ubiquitin carboxyl-terminal hydrolase 22|ubiquitin specific protease 22|ubiquitin thioesterase 22|ubiquitin thiolesterase 22|ubiquitin-specific-processing protease 22
|
| Swissprots |
Q6PDX3 Q8BJG3 Q5SU81 Q5DU02 Q3TU34 Q66JV8 Q3U2W4
|
| Accessions |
Q5DU02 AK034492 AK040187 BAE20573 AK084022 BAC39100 AK155071 BAE33026 AK160992 BAE36137 AK190293 AK191821 AK193842 AK197775 AK197836 AK198335 AK199010 AK200101 AK201946 AK202584 AK203434 AK204675 AK218257 AK220368 BAD90248 BC026701 BC052540 BC058419 AAH58419 BC080737 AAH80737 NM_001004143 NP_001004143
|
| Function |
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain and weakly in other organs. {ECO:0000269|PubMed:16378762}.
|