Gene Symbol | IL31RA |
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Entrez Gene | 133396 |
Alt Symbol | CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R |
Species | Human |
Gene Type | protein-coding |
Description | interleukin 31 receptor A |
Other Description | IL-31 receptor subunit alpha|IL-31R subunit alpha|class I cytokine receptor|cytokine receptor-like 3|gp130-like monocyte receptor|interleukin-31 receptor subunit alpha|soluble type I cytokine receptor CRL3|zcytoR17 |
Swissprots | Q8WYJ0 Q6EBC3 Q8NI17 A6NIF8 Q6EBC5 Q6EBC6 Q2TBA1 Q6UWL8 Q6EBC4 |
Accessions | CAD23785 CAD23791 CAL44874 CAL44875 CAV32860 CAX21675 CAX21676 CAX87001 CAX87002 CBL94050 CBL94051 CBX32718 CBY79717 CBY79723 CDM63721 CDM63722 CEF37152 CEF37160 EAW54930 EAW54931 EAW54932 EAW54933 EAW54934 Q8NI17 AF106913 AAL36452 AF486620 AAM27958 AK297938 BAG60254 AY358117 AAQ88484 AY358740 AAQ89100 AY499339 AAS86444 AY499340 AAS86445 AY499341 AAS86446 AY499342 AAS86447 BC110490 AAI10491 BG194774 XM_011543142 XP_011541444 XM_011543143 XP_011541445 XM_011543144 XP_011541446 XM_011543145 XP_011541447 NM_001242636 NP_001229565 NM_001242637 NP_001229566 NM_001242638 NP_001229567 NM_001242639 NP_001229568 NM_001297570 NP_001284499 NM_001297572 NP_001284501 NM_139017 NP_620586 |
Function | Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. {ECO:0000269|PubMed:11877449, ECO:0000269|PubMed:14504285, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:15194700, ECO:0000269|PubMed:15627637}. |
Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14- and CD56-positive blood cells and by macrophages (at protein level). {ECO:0000269|PubMed:11877449, ECO:0000269|PubMed:14504285, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:16461143}. |
IL-31R CRISPR/Cas9 KO Plasmid (h) - sc-416770 from Santa Cruz Biotechnology
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IL-31R HDR Plasmid (h) - sc-416770-HDR from Santa Cruz Biotechnology
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IL-31R Double Nickase Plasmid (h) - sc-416770-NIC from Santa Cruz Biotechnology
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IL-31R Double Nickase Plasmid (h2) - sc-416770-NIC-2 from Santa Cruz Biotechnology
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IL-31R CRISPR Activation Plasmid (h) - sc-416770-ACT from Santa Cruz Biotechnology
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IL-31R CRISPR Activation Plasmid (h2) - sc-416770-ACT-2 from Santa Cruz Biotechnology
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IL-31R Lentiviral Activation Particles (h) - sc-416770-LAC from Santa Cruz Biotechnology
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IL-31R Lentiviral Activation Particles (h2) - sc-416770-LAC-2 from Santa Cruz Biotechnology
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IL-31R siRNA (h) - sc-60839 from Santa Cruz Biotechnology
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IL-31R shRNA Plasmid (h) - sc-60839-SH from Santa Cruz Biotechnology
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IL-31R shRNA (h) Lentiviral Particles - sc-60839-V from Santa Cruz Biotechnology
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IL-31 RA RNAi - H00133396-R01V from Novus Biologicals
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MISSION® esiRNA - EHU081121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10628 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10628 from Sigma-Aldrich
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IL31RA siRNA (Human) - CRJ5114 from Cohesion Biosciences
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IL-31 RA RNAi - H00133396-R02 from Novus Biologicals
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IL31RA - MBS8216294 from MyBioSource
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shRNA set against Human IL31RA (NM_139017.5) - SHH318909 from Creative biogene
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IL31RA shRNA Plasmid (Human) - CHJ5114 from Cohesion Biosciences
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IL31RA miRNA 3'UTR clone - MiUTR4H-TG04506 from Creative biogene
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