| Gene Symbol | CD58 |
|---|---|
| Entrez Gene | 965 |
| Alt Symbol | LFA-3, LFA3, ag3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD58 molecule |
| Other Description | CD58 antigen, (lymphocyte function-associated antigen 3)|lymphocyte function-associated antigen 3|surface glycoprotein LFA-3 |
| Swissprots | A8K7G5 P19256 Q96KI9 Q6IB65 Q5U053 |
| Accessions | CAA75083 CAA75084 CAJ86521 CBX51827 CDM22273 EAW56652 EAW56653 EAW56654 EAW56655 EAW56656 P19256 AK125710 AK291980 BAF84669 BC005930 AAH05930 BT019816 AAV38619 BT019817 AAV38620 CA312671 CD365881 CR456939 CAG33220 D28586 BAA05922 EF491785 S79616 AAB40000 X06296 CAA29622 Y00636 CAA68668 NM_001144822 NP_001138294 NM_001779 NP_001770 NR_026665 |
| Function | Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. |
| Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
| Top Pathways | Cell adhesion molecules (CAMs), Epstein-Barr virus infection |