Gene Symbol | CD58 |
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Entrez Gene | 965 |
Alt Symbol | LFA-3, LFA3, ag3 |
Species | Human |
Gene Type | protein-coding |
Description | CD58 molecule |
Other Description | CD58 antigen, (lymphocyte function-associated antigen 3)|lymphocyte function-associated antigen 3|surface glycoprotein LFA-3 |
Swissprots | A8K7G5 P19256 Q96KI9 Q6IB65 Q5U053 |
Accessions | CAA75083 CAA75084 CAJ86521 CBX51827 CDM22273 EAW56652 EAW56653 EAW56654 EAW56655 EAW56656 P19256 AK125710 AK291980 BAF84669 BC005930 AAH05930 BT019816 AAV38619 BT019817 AAV38620 CA312671 CD365881 CR456939 CAG33220 D28586 BAA05922 EF491785 S79616 AAB40000 X06296 CAA29622 Y00636 CAA68668 NM_001144822 NP_001138294 NM_001779 NP_001770 NR_026665 |
Function | Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen- presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
Top Pathways | Cell adhesion molecules (CAMs), Epstein-Barr virus infection |
CD58 CRISPR/Cas9 KO Plasmid (h) - sc-407914 from Santa Cruz Biotechnology
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CD58 HDR Plasmid (h) - sc-407914-HDR from Santa Cruz Biotechnology
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CD58 Double Nickase Plasmid (h) - sc-407914-NIC from Santa Cruz Biotechnology
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CD58 Double Nickase Plasmid (h2) - sc-407914-NIC-2 from Santa Cruz Biotechnology
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CD58 CRISPR Activation Plasmid (h) - sc-407914-ACT from Santa Cruz Biotechnology
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CD58 CRISPR Activation Plasmid (h2) - sc-407914-ACT-2 from Santa Cruz Biotechnology
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CD58 Lentiviral Activation Particles (h) - sc-407914-LAC from Santa Cruz Biotechnology
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CD58 Lentiviral Activation Particles (h2) - sc-407914-LAC-2 from Santa Cruz Biotechnology
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CD58 siRNA (h) - sc-42799 from Santa Cruz Biotechnology
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CD58 shRNA Plasmid (h) - sc-42799-SH from Santa Cruz Biotechnology
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CD58 shRNA (h) Lentiviral Particles - sc-42799-V from Santa Cruz Biotechnology
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CD58/LFA-3 RNAi - H00000965-R01 from Novus Biologicals
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MISSION® esiRNA - EHU149591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5739 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5739 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02229 from Sigma-Aldrich
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CD58 siRNA (Human) - CRH0686 from Cohesion Biosciences
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CD58 - MBS8228464 from MyBioSource
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shRNA set against Human CD58 (NM_001779.2) - SHH259221 from Creative biogene
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Human CD58 siRNA - orb261188 from Biorbyt
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CD58 shRNA Plasmid (Human) - CHH0686 from Cohesion Biosciences
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CD58 miRNA 3'UTR clone - MiUTR3H-01354 from Creative biogene
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CD58 miRNA 3'UTR clone - MiUTR3H-01355 from Creative biogene
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