| Gene Symbol |
H2AFJ
|
| Entrez Gene |
55766
|
| Alt Symbol |
H2AJ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
H2A histone family, member J
|
| Other Description |
H2a/j|buforin I|histone H2A.J
|
| Swissprots |
Q9NV63 Q9BTM1
|
| Accessions |
EAW96326 EAW96327 Q9BTM1 AK001765 BAA91894 AK303301 BAG64375 AL133626 BC003602 AAH03602 BM689354 BQ438653 BU594879 DA808847 DB084616 HQ447950 ADQ32434 NM_177925 NP_808760 NR_027716 NM_018267
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
|
| Top Pathways |
Systemic lupus erythematosus, Alcoholism
|
![Western Blot: H2AFJ Overexpression Lysate (Adult Normal) [NBL1-11422] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for H2AFJ.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4546_H2AFJ%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11422-img0002.jpg)