| Gene Symbol |
MAGI1
|
| Entrez Gene |
9223
|
| Alt Symbol |
AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, Magi1d, TNRC19, WWP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
membrane associated guanylate kinase, WW and PDZ domain containing 1
|
| Other Description |
BAI1-associated protein 1|WW domain-containing protein 3|atrophin-1-interacting protein 3|membrane-associated guanylate kinase inverted 1|membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1|trinucleotide repeat-containing gene 19 protein
|
| Swissprots |
Q96QZ8 O75085 A8K188 Q96QZ9 O43863 O00309 Q96QZ7
|
| Accessions |
EAW65439 EAW65440 EAW65441 EAW65442 EAW65443 EAW65444 EAW65445 Q96QZ7 AB010894 BAA32002 AF088016 AF401654 AAK94064 AF401655 AAK94065 AF401656 AAK94066 AK023358 AK124433 AK127518 AK130632 AK289803 BAF82492 AK307794 AK310365 AL050184 BC062367 BC167863 AAI67863 HG495754 KC170987 AGT57742 U80754 AAC04844 U96115 AAC51326 XM_005265563 XP_005265620 XM_005265564 XP_005265621 XM_005265565 XP_005265622 XM_005265566 XP_005265623 XM_005265568 XP_005265625 XM_005265570 XP_005265627 XM_005265571 XP_005265628 XM_005265574 XP_005265631 XM_006713407 XP_006713470 XM_006713408 XP_006713471 XM_006713409 XP_006713472 XM_006713410 XP_006713473 XM_006713411 XP_006713474 XM_006713412 XP_006713475 XM_006713413 XP_006713476 XM_006713414 XP_006713477 XM_011534236 XP_011532538 XM_011534237 XP_011532539 XM_011534238 XP_011532540 XM_011534239 XP_011532541 XM_011534240 XP_011532542 XM_011534241 XP_011532543 NM_001033057 NP_001028229 NM_004742 NP_004733 NM_015520 NP_056335
|
| Function |
May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell junction, tight junction {ECO:0000269|PubMed:11969287}. Cell membrane {ECO:0000269|PubMed:11969287}; Peripheral membrane protein {ECO:0000269|PubMed:11969287}. Note=Localizes to epithelial cells tight junctions.
|
| Tissue Specificity |
Widely expressed with the exception of skeletal muscle. Isoform 1, isoform 2 and isoform 6 are highly expressed in colon, kidney, lung, liver, and pancreas. Isoform 5 is predominantly expressed in brain and heart. Isoform 3 and isoform 4 are highly expressed in pancreas and brain. {ECO:0000269|PubMed:11969287, ECO:0000269|PubMed:9647693, ECO:0000269|PubMed:9647739}.
|
| Top Pathways |
Tight junction, Rap1 signaling pathway
|