| Gene Symbol | Hspa5 |
|---|---|
| Entrez Gene | 14828 |
| Alt Symbol | AL022860, AU019543, Bip, D2Wsu141e, D2Wsu17e, Grp78, Hsce70, SEZ-7, Sez7, baffled, mBiP |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | heat shock protein 5 |
| Other Description | 78 kDa glucose-regulated protein|GRP-78|XAP-1 antigen|glucose regulated protein, 78 kDa|heat shock 70 kDa protein 5|heat shock 70kD protein 5 (glucose-regulated protein, 78kD)|immunoglobulin heavy chain-binding protein |
| Swissprots | Q3UFF2 O35642 Q61630 P20029 |
| Accessions | AAA76734 EDL08616 EDL08617 EDL08618 P20029 AJ002387 CAA05361 AK004578 BAB23387 AK076079 BAC36166 AK077463 AK144650 AK144742 AK146647 BAE27328 AK148539 BAE28609 AK149447 BAE28883 AK151244 AK151647 BAE30576 AK151806 BAE30705 AK152020 BAE30882 AK152521 BAE31281 AK152958 BAE31621 AK159719 BAE35314 AK160592 BAE35899 AK160821 AK166207 AK166739 BAE38982 AK167011 BAE39187 AK168012 BAE39999 AK168230 AK169034 BAE40825 AK178434 AK178841 AK180947 AK181293 AK185871 AK186478 AK188133 AK188254 AK192310 AK192496 AK194376 AK194508 AK195133 AK196010 AK197130 AK197258 AK197968 AK198470 AK198632 AK198934 AK199027 AK200033 AK203208 AK204137 AK204292 AK206130 AK206500 AK206677 AK206732 AK207319 AK207523 AK207843 AK208906 AK209206 AK212207 AK213049 AK213790 AK214147 AK215158 AK215673 AK216390 AK218616 AK219238 AK219322 BC005785 BC050927 AAH50927 D78645 BAA11462 M19351 AAA37315 M30779 AAA37742 U89425 AAC36531 NM_001163434 NP_001156906 NM_022310 NP_071705 |
| Function | Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:21992152}. Melanosome {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:21992152}. |
| Top Pathways | Protein export, Prion diseases, Protein processing in endoplasmic reticulum, Thyroid hormone synthesis, Antigen processing and presentation |
GRP 78 CRISPR/Cas9 KO Plasmid (m) - sc-420699 from Santa Cruz Biotechnology
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GRP 78 HDR Plasmid (m) - sc-420699-HDR from Santa Cruz Biotechnology
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GRP 78 Double Nickase Plasmid (m) - sc-420699-NIC from Santa Cruz Biotechnology
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GRP 78 Double Nickase Plasmid (m2) - sc-420699-NIC-2 from Santa Cruz Biotechnology
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GRP 78 CRISPR Activation Plasmid (m) - sc-420699-ACT from Santa Cruz Biotechnology
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GRP 78 CRISPR Activation Plasmid (m2) - sc-420699-ACT-2 from Santa Cruz Biotechnology
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GRP 78 Lentiviral Activation Particles (m) - sc-420699-LAC from Santa Cruz Biotechnology
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GRP 78 Lentiviral Activation Particles (m2) - sc-420699-LAC-2 from Santa Cruz Biotechnology
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GRP 78 siRNA (m) - sc-35522 from Santa Cruz Biotechnology
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GRP 78 shRNA Plasmid (m) - sc-35522-SH from Santa Cruz Biotechnology
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GRP 78 shRNA (m) Lentiviral Particles - sc-35522-V from Santa Cruz Biotechnology
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GRP 78 siRNA (m2) - sc-44303 from Santa Cruz Biotechnology
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GRP 78 shRNA Plasmid (m2) - sc-44303-SH from Santa Cruz Biotechnology
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GRP 78 shRNA (m2) Lentiviral Particles - sc-44303-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU051691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33525 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33525 from Sigma-Aldrich
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HSPA5 siRNA (Mouse) - CRM1701 from Cohesion Biosciences
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HSPA5 - MBS8214040 from MyBioSource
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shRNA set against Mouse HSPA5 (NM_022310.3) - SHH315617 from Creative biogene
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HSPA5 shRNA Plasmid (Mouse) - CHM1701 from Cohesion Biosciences
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