TRPC4AP
| Gene Symbol | TRPC4AP |
|---|---|
| Entrez Gene | 26133 |
| Alt Symbol | C20orf188, PPP1R158, TRRP4AP, TRUSS |
| Species | Human |
| Gene Type | protein-coding |
| Description | transient receptor potential cation channel, subfamily C, member 4 associated protein |
| Other Description | TNF-receptor ubiquitous scaffolding/signaling protein|TRP4-associated protein|protein phosphatase 1, regulatory subunit 158|short transient receptor potential channel 4 associated protein|short transient receptor potential channel 4-associated protein|trpc4-associated protein|tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein |
| Swissprots | Q9H429 E1P5Q0 Q96H82 E1P5Q1 Q8TEL6 Q9UFS6 Q9BVB8 |
| Accessions | CCQ43520 EAW76229 EAW76230 EAW76231 EAW76232 EAW76233 EAW76234 EAW76235 Q8TEL6 AF055022 AK074106 BAB84932 AK298958 BAG61054 AK301368 BAG62910 AK303476 BAG64513 AK315582 BAG37955 AL096738 AL117480 CAB55953 BC001323 AAH01323 BC008836 AAH08836 BC013144 AAH13144 BI488542 BM149369 BM723903 CF125531 JF432334 ADZ15551 XM_011528770 XP_011527072 XM_011528771 XP_011527073 XM_011528772 XP_011527074 XM_011528773 XP_011527075 XM_011528774 XP_011527076 XR_936516 XR_936517 NM_015638 NP_056453 NM_199368 NP_955400 |
| Function | Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. {ECO:0000269|PubMed:20551172}. |
TRPC4AP CRISPR/Cas9 KO Plasmid (h) - sc-411882 from Santa Cruz Biotechnology
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TRPC4AP HDR Plasmid (h) - sc-411882-HDR from Santa Cruz Biotechnology
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TRPC4AP Double Nickase Plasmid (h) - sc-411882-NIC from Santa Cruz Biotechnology
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TRPC4AP Double Nickase Plasmid (h2) - sc-411882-NIC-2 from Santa Cruz Biotechnology
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TRPC4AP CRISPR Activation Plasmid (h) - sc-411882-ACT from Santa Cruz Biotechnology
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TRPC4AP CRISPR Activation Plasmid (h2) - sc-411882-ACT-2 from Santa Cruz Biotechnology
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TRPC4AP Lentiviral Activation Particles (h) - sc-411882-LAC from Santa Cruz Biotechnology
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TRPC4AP Lentiviral Activation Particles (h2) - sc-411882-LAC-2 from Santa Cruz Biotechnology
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TRPC4AP siRNA (h) - sc-76758 from Santa Cruz Biotechnology
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TRPC4AP shRNA Plasmid (h) - sc-76758-SH from Santa Cruz Biotechnology
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TRPC4AP shRNA (h) Lentiviral Particles - sc-76758-V from Santa Cruz Biotechnology
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TRUSS RNAi - H00026133-R01 from Novus Biologicals
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TRUSS RNAi - H00026133-R02 from Novus Biologicals
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MISSION® esiRNA - EHU001061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22056 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22056 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06097 from Sigma-Aldrich
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TRPC4AP siRNA (Human) - CRH8724 from Cohesion Biosciences
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TRPC4AP - MBS8202714 from MyBioSource
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shRNA set against Human TRPC4AP (NM_199368.1) - SHH435572 from Creative biogene
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shRNA set against Human TRPC4AP(NM_015638.2) - SHL096996 from Creative biogene
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Human TRPC4AP siRNA - orb269226 from Biorbyt
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TRPC4AP shRNA Plasmid (Human) - CHH8724 from Cohesion Biosciences
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TRPC4AP miRNA 3'UTR clone - MiUTR1H-10782 from Creative biogene
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TRPC4AP miRNA 3'UTR clone - MiUTR1H-10783 from Creative biogene
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