ACKR3

Gene Symbol	ACKR3
Entrez Gene	57007
Alt Symbol	CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1
Species	Human
Gene Type	protein-coding
Description	atypical chemokine receptor 3
Other Description	C-X-C chemokine receptor type 7|G protein-coupled receptor|G-protein coupled receptor 159|G-protein coupled receptor RDC1 homolog|chemokine (C-X-C motif) receptor 7|chemokine orphan receptor 1
Swissprots	Q92986 A8K6J4 Q8NE10 P25106 Q92938 Q53RV4
Accessions	AAB18130 AAX93086 CCE67098 CCE67101 EAW71092 P25106 AF030297 AAB94130 AK291659 BAF84348 BC008459 BC036661 AAH36661 BM925428 BP426139 DB455412 DQ822477 ABH01258 DQ891241 ABM82167 DQ894426 ABM85352 M64749 AAA62370 U67784 AAB16913 XM_005246097 XP_005246154 XM_005246098 XP_005246155 XM_011511503 XP_011509805 NM_020311 NP_064707 NM_001047841
Function	Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein- mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL1
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Early endosome. Recycling endosome {ECO:0000250}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin- coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Tissue Specificity	Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue (at protein level). {ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:16455976, ECO:0000269|PubMed:19641136, ECO:0000269|PubMed:20388803, ECO:0000269|PubMed:20887389, ECO:0000269|PubMed:21655198}.
Top Pathways	Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ACKR3 / CXCR7 ELISA Kit (Sandwich ELISA) - LS-F7336 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.156-10 ng/ml

Human ACKR3 / CXCR7 ELISA Kit (Sandwich ELISA) - LS-F11260 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human CXCR7 ELISA Kit - abx151217 from Abbexa Category ELISA Kit Sensitivity 0.058 ng/ml Range 0.156 ng/ml - 10 ng/ml

C-X-C chemokine receptor type 7, CXCR7, Human, ELISA Kit - E9240h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 0.312-20 ng/mL

CXC-chemokine receptor 7 (CXCR7), Human, ELISA Kit - CSB-E13854h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

CXC-chemokine receptor 7 (CXCR7), Human, ELISA Kit - E01C2200 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

chemokine (C-X-C motif) receptor 7, ELISA Kit - MBS704512 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CXCR7 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 25 pg/ml -1600 pg/ml.

ELISA Kit for Chemokine C-X-C-Motif Receptor 7 (CXCR7) - SEB488Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human CXC-chemokine receptor 7(CXCR7)ELISA Kit - CSB-E13854h from Cusabio Category ELISA Kit Sensitivity 6.25 pg/ml Range 25 pg/ml-1600 pg/ml

ELISA Kit for Chemokine C-X-C-Motif Receptor 7 (CXCR7) - SEB488Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse ACKR3 / CXCR7 ELISA Kit (Sandwich ELISA) - LS-F20361 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.156-10 ng/ml

Dog ACKR3 / CXCR7 ELISA Kit (Custom ELISA) - LS-F20362 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Rat ACKR3 / CXCR7 ELISA Kit (Custom ELISA) - LS-F20360 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Human C-X-C chemokine receptor type 7 ELISA Kit - abx251823 from Abbexa Category ELISA Kit Range 0.312 ng/ml - 20 ng/ml

Chemokine C-X-C-Motif Receptor 7 (CXCR7), Human, ELISA Kit - DL-CXCR7-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human ACKR3 / CXCR7 ELISA Kit (Sandwich ELISA) - LS-F26917 from LifeSpan Bioscience Category ELISA Kit Prices $870.00 Sizes 1 plate Sensitivity 0.1 ng/ml Range 0.156-10 ng/ml

Human CXCR7 ELISA Kit - abx571019 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human C-X-C chemokine receptor type 7 ELISA Kit - EKE55205 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.12 ng/mL Range 0.312-20 ng/mL

CXCR7 - EKH4916 from Nordic BioSite Sensitivity 0.188ng/ml Range 0.312-20ng/ml

CXCR7 ELISA Kit (Human) (OKEH01934) - OKEH01934 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.12 ng/mL Range 0.312 - 20 ng/mL

Human CXCR7 ELISA Kit - E007999 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human CXCR7 is typically less than 6.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the me

Human ACKR3 ELISA Kit - E074418 from Biobool Category ELISA Kit

Human C-X-C chemokine receptor type 7 ELISA Kit - EK4934 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 34pg/mL Range 78-5000 pg/mL

anti-CXCR7 antibody - ARG56565 from Arigo Biolaboratories Category ELISA Kit

Human CXC-chemokine receptor 7 (CXCR7) ELISA Kit - AE58957HU from ARP American Research Products Category ELISA Kit Prices $612.00 Sizes 96 t Sensitivity 0.056 ng/mL Range 0.156-10 ng/mL

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