| Gene Symbol |
ADAP1
|
| Entrez Gene |
11033
|
| Alt Symbol |
CENTA1, GCS1L, p42IP4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with dual PH domains 1
|
| Other Description |
arf-GAP with dual PH domain-containing protein 1|centaurin, alpha 1|centaurin-alpha|centaurin-alpha-1|cnt-a1|putative MAPK-activating protein PM25
|
| Swissprots |
O75689 B4DVA6 A4D2Q2 F6XZ68 H7C2Q4 B3KRZ4
|
| Accessions |
EAL23709 EAW87182 EAW87183 EAW87184 O75689 AB097049 BAC77402 AF082324 AAD11414 AI910700 AJ006422 CAA07024 AK092471 BAG52556 AK124979 BAG54118 AK290517 BAF83206 AK300644 BAG62332 AK300859 BAG62509 AK300999 BAG62618 BC033747 AAH33747 BG716328 BM837987 CR975507 DA872042 NM_001284308 NP_001271237 NM_001284309 NP_001271238 NM_001284310 NP_001271239 NM_001284311 NP_001271240 NM_006869 NP_006860
|
| Function |
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). {ECO:0000269|PubMed:10448098, ECO:0000303|PubMed:10333475, ECO:0000305}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.
|
| Tissue Specificity |
Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes. {ECO:0000269|PubMed:10448098}.
|
