| Gene Symbol |
RBM15
|
| Entrez Gene |
64783
|
| Alt Symbol |
OTT, OTT1, SPEN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA binding motif protein 15
|
| Other Description |
RNA-binding motif protein 15|one twenty two protein|one twenty-two|one-twenty two protein 1|putative RNA-binding protein 15
|
| Swissprots |
Q86VW9 Q9BRA5 Q4V760 Q5T613 Q5D058 Q3ZB86 Q96SD0 Q96T37 A1A693 Q96T38 Q9H6R8 Q96SC9 Q9H9Y0 Q96PE4
|
| Accessions |
CAC38861 CAC38862 EAW56438 EAW56439 EAW56440 Q96T37 AB209680 BAD92917 AF368062 AAK54722 AF368063 AAK54723 AF368064 AAK54724 AI863760 AK022541 BAB14088 AK025596 BAB15185 AW173262 BC000841 BC006397 AAH06397 BC010891 BC042587 BC047479 AAH47479 BC062316 AAH62316 BC098140 AAH98140 BC103493 AAI03494 BC103507 AAI03508 BC103660 BK005915 DAA05818 XM_011541964 XP_011540266 XM_011541965 XP_011540267 XM_011541966 XP_011540268 XM_011541967 XP_011540269 XM_011541968 XP_011540270 XM_011541969 XP_011540271 NM_001201545 NP_001188474 NM_022768 NP_073605
|
| Function |
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation. {ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495}.
|
| Subcellular Location |
Nucleus. Nucleus membrane; Peripheral membrane protein. Note=Colocalizes at the nuclear pore with DBP5 and NXF1.
|
