| Gene Symbol | SEPT11 |
|---|---|
| Entrez Gene | 55752 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | septin 11 |
| Other Description | septin-11 |
| Swissprots | Q7L4N1 Q4W5G1 Q96SP1 E9KL32 Q9UFY9 B7Z7Z6 Q9NVA2 |
| Accessions | AAY40922 EAX05803 EAX05804 EAX05805 Q9NVA2 AI580485 AI741944 AK001711 BAA91853 AK027279 BAB55014 AK027633 BAB55250 AK094473 AK124592 AK302700 BAH13782 AL110300 CAB53741 BC008083 AAH08083 BC063615 AAH63615 BC064934 BQ021538 BQ221260 CA394082 CA422047 CR627457 CR997215 CX870938 DA413789 DA497699 DA803364 GU727629 ADU87631 XM_005263120 XP_005263177 XM_006714259 XP_006714322 XM_011532107 XP_011530409 NM_001306147 NP_001293076 NM_018243 NP_060713 |
| Function | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy. {ECO:0000250, ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:19234302, ECO:0000305}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cell junction, synapse. Cell projection, dendritic spine. Cell projection, axon {ECO:0000250}. Note=Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. |
| Tissue Specificity | Widely expressed, except in leukocytes. {ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:15915442}. |
| Top Pathways | Bacterial invasion of epithelial cells |
Septin 11 CRISPR/Cas9 KO Plasmid (h) - sc-407969 from Santa Cruz Biotechnology
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Septin 11 HDR Plasmid (h) - sc-407969-HDR from Santa Cruz Biotechnology
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Septin 11 Double Nickase Plasmid (h) - sc-407969-NIC from Santa Cruz Biotechnology
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Septin 11 Double Nickase Plasmid (h2) - sc-407969-NIC-2 from Santa Cruz Biotechnology
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Septin 11 CRISPR Activation Plasmid (h) - sc-407969-ACT from Santa Cruz Biotechnology
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Septin 11 CRISPR Activation Plasmid (h2) - sc-407969-ACT-2 from Santa Cruz Biotechnology
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Septin 11 Lentiviral Activation Particles (h) - sc-407969-LAC from Santa Cruz Biotechnology
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Septin 11 Lentiviral Activation Particles (h2) - sc-407969-LAC-2 from Santa Cruz Biotechnology
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Septin-11 siRNA (h) - sc-61534 from Santa Cruz Biotechnology
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Septin-11 shRNA Plasmid (h) - sc-61534-SH from Santa Cruz Biotechnology
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Septin-11 shRNA (h) Lentiviral Particles - sc-61534-V from Santa Cruz Biotechnology
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Septin-11 RNAi - H00055752-R01 from Novus Biologicals
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MISSION® esiRNA - EHU000211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19100 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19100 from Sigma-Aldrich
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SEPT11 siRNA (Human) - CRJ0890 from Cohesion Biosciences
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SEPT11 - MBS8236064 from MyBioSource
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shRNA set against Human SEPT11 (NM_018243.2) - SHH404612 from Creative biogene
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shRNA set against Human SEPT11(NM_018243.2) - SHR215240 from Creative biogene
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Human SEPT11 siRNA - orb271391 from Biorbyt
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SEPT11 shRNA Plasmid (Human) - CHJ0890 from Cohesion Biosciences
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SEPT11 miRNA 3'UTR clone - MiUTR1H-09273 from Creative biogene
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