| Gene Symbol |
HDAC4
|
| Entrez Gene |
9759
|
| Alt Symbol |
AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone deacetylase 4
|
| Other Description |
histone deacetylase A
|
| Swissprots |
Q86YH7 Q9UND6 F5GX36 P56524 E9PGB9
|
| Accessions |
AAX93070 AAX93254 EAW71165 EAW71166 P56524 AB006626 BAA22957 AF070607 AF132607 AAD29046 AI199675 AI654062 AK302719 BAH13789 AK303368 BAH13951 AK303467 BAH13968 AK303617 BAH13999 AK308791 AK310488 AK310603 AK311582 BC039904 AAH39904 BQ576173 XM_006712877 XP_006712940 XM_006712878 XP_006712941 XM_006712879 XP_006712942 XM_006712880 XP_006712943 XM_011512217 XP_011510519 XM_011512218 XP_011510520 XM_011512219 XP_011510521 XM_011512220 XP_011510522 XM_011512221 XP_011510523 XM_011512222 XP_011510524 XM_011512223 XP_011510525 XM_011512224 XP_011510526 XM_011512225 XP_011510527 XM_011512226 XP_011510528 XM_011512227 XP_011510529 XM_011512228 XP_011510530 XM_011512229 XP_011510531 XM_011512230 XP_011510532 NM_006037 NP_006028
|
| Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Viral carcinogenesis, Epstein-Barr virus infection, Alcoholism, MicroRNAs in cancer
|