AKAP13

Gene Symbol	AKAP13
Entrez Gene	11214
Alt Symbol	AKAP-13, AKAP-Lbc, ARHGEF13, BRX, HA-3, Ht31, LBC, PRKA13, PROTO-LB, PROTO-LBC, c-lbc, p47
Species	Human
Gene Type	protein-coding
Description	A kinase (PRKA) anchor protein 13
Other Description	A-kinase anchor protein 13|A-kinase anchoring protein|LBC oncogene|breast cancer nuclear receptor-binding auxiliary protein|guanine nucleotide exchange factor Lbc|human thyroid-anchoring protein 31|lymphoid blast crisis oncogene|non-oncogenic Rho GTPase-specific GTP exchange factor|protein kinase A-anchoring protein 13
Swissprots	Q9Y5T6 Q96P79 Q9Y5T0 Q8WXQ6 Q59FP6 Q96JP6 Q86W90 Q14572 Q12802
Accessions	EAX01973 EAX01974 EAX01975 EAX01976 Q12802 AB055890 BAB62913 AB209414 BAD92651 AF086293 AF126008 AAD21311 AF387101 AAL40923 AF406992 AAL11723 AK022014 AK026186 AK091210 AK125331 AK307618 AK309805 AK315885 BAF98776 AL133426 AL133427 AL133429 AL133430 AL135297 BC000269 BC009213 BC017368 BC019662 BC040109 BC050312 AAH50312 BC063592 BC089394 BC140862 AAI40863 BC171798 AAI71798 BC172356 AAI72356 CA306665 KC832804 M90360 AAA58670 NM_001270546 NP_001257475 NM_006738 NP_006729 NM_007200 NP_009131 NM_144767
Function	Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
Subcellular Location	Cytoplasm. Nucleus. Membrane.
Tissue Specificity	Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen- responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AKAP 13 CRISPR/Cas9 KO Plasmid (h) - sc-404368 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

AKAP 13 HDR Plasmid (h) - sc-404368-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

AKAP 13 Double Nickase Plasmid (h) - sc-404368-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

AKAP 13 Double Nickase Plasmid (h2) - sc-404368-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

AKAP 13 CRISPR Activation Plasmid (h) - sc-404368-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

AKAP 13 CRISPR Activation Plasmid (h2) - sc-404368-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

AKAP 13 Lentiviral Activation Particles (h) - sc-404368-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

AKAP 13 Lentiviral Activation Particles (h2) - sc-404368-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

AKAP 13 siRNA (h) - sc-41721 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

AKAP 13 shRNA Plasmid (h) - sc-41721-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

AKAP 13 shRNA (h) Lentiviral Particles - sc-41721-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

AKAP13 RNAi - H00011214-R11 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

AKAP13 RNAi - H00011214-R12 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU124271 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0093 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0091 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0092 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN3005 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3005 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

AKAP13 siRNA (Human) - CRH7683 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

AKAP13 RNAi - H00011214-R10 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

AKAP13 - MBS8202706 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

AKAP13 shRNA Plasmid (Human) - CHH7683 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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