| Gene Symbol |
CD109
|
| Entrez Gene |
135228
|
| Alt Symbol |
CPAMD7, p180, r150
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD109 molecule
|
| Other Description |
150 kDa TGF-beta-1-binding protein|C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7|CD109 antigen|Gov platelet alloantigens|activated T-cell marker CD109|platelet-specific Gov antigen
|
| Swissprots |
Q8N3A7 A5YKK4 Q0P6K7 Q5XUM9 B3KW25 Q5XUM7 Q6MZI7 Q5SYA8 Q8TDJ2 B2R948 Q6YHK3 Q8N915 Q8TDJ3
|
| Accessions |
AAL84160 AAU94640 AAU94641 AAU94642 AAU94643 AAU94644 AAU94645 ADZ28543 EAW48752 EAW48753 EAW48754 EAW48755 Q6YHK3 AF410459 AAL84159 AK095888 BAC04642 AK123960 BAG53987 AK130104 AK313636 BAG36395 AL110152 AL834478 CAD39137 AY149920 AAN78483 AY374441 AY374442 AY788891 AAX14639 BC148364 AAI48365 BC152996 AAI52997 BM722643 BP279681 BP351448 BX107999 BX641095 CAE46045 BX646244 CB529476 CB853216 DA720168 DB280225 EF553520 ABQ66266 XM_005248659 XP_005248716 XM_011535473 XP_011533775 XM_011535474 XP_011533776 NM_001159587 NP_001153059 NM_001159588 NP_001153060 NM_133493 NP_598000
|
| Function |
Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000269|PubMed:16754747}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11861284, ECO:0000269|PubMed:16754747}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11861284, ECO:0000269|PubMed:16754747}.
|
| Tissue Specificity |
Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. {ECO:0000269|PubMed:11861284, ECO:0000269|PubMed:14980714, ECO:0000269|PubMed:16754747}.
|