| Gene Symbol |
MCM5
|
| Entrez Gene |
850980
|
| Alt Symbol |
BOB1, CDC46
|
| Species |
Yeast
|
| Gene Type |
protein-coding
|
| Description |
MCM DNA helicase complex subunit MCM5
|
| Other Description |
-
|
| Swissprots |
P29496 D6VYS1
|
| Accessions |
DAA09587 P29496 NM_001182161 NP_013376
|
| Function |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; specifically the MCM2-MCM5 association is proposed to be reversible and to mediate a open ring conformation which may facilitate DNA loading. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. {ECO:0000269|PubMed:19896182, ECO:0000269|PubMed:19910535}.
|
| Subcellular Location |
Nucleus. Note=Mobilized from the cytoplasm to the nucleus as mitosis is completed. Remains in the nucleus until the initiation of the next round of replication.
|
| Top Pathways |
DNA replication, Cell cycle - yeast, Meiosis - yeast
|