PLAT

Gene Symbol	PLAT
Entrez Gene	5327
Alt Symbol	T-PA, TPA
Species	Human
Gene Type	protein-coding
Description	plasminogen activator, tissue
Other Description	alteplase|plasminogen activator, tissue type|reteplase|t-plasminogen activator|tissue plasminogen activator (t-PA)|tissue-type plasminogen activator
Swissprots	A8K022 Q9BU99 Q86YK8 Q9BZW1 Q7Z7N2 B2R8E8 Q503B0 P00750 Q15103 Q6PJA5
Accessions	AAA61213 AAA98809 AAB59510 AAP34246 CAA00166 CAA54669 CAJ18783 CAL48222 EAW63231 EAW63232 EAW63233 EAW63234 EAW63235 P00750 A03776 CAA00299 A07197 CAA00642 AF260825 AAK11956 AF282882 AAM52248 AK289387 BAF82076 AK290575 BAF83264 AK297738 BAG60088 AK297937 BAG60253 AK299205 BAG61245 AK300984 BAG62604 AK313342 BAG36145 AY221101 AAO34406 BC002795 AAH02795 BC007231 AAH07231 BC013968 AAH13968 BC018636 AAH18636 BC095403 AAH95403 BT007060 AAP35709 BX641021 CAI46259 D01096 BAA00881 DA031108 DA549782 DQ893499 ABM84425 DQ896487 ABM87486 EU831423 ACE87110 EU831516 ACE86435 FM956488 CAX11668 M15518 AAA60111 M18182 AAA36800 M26666 V00570 CAA23833 X02901 X07393 CAA30302 X13097 CAA31489 NM_000930 NP_000921 NM_033011 NP_127509 NM_000931
Function	Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Subcellular Location	Secreted, extracellular space.
Tissue Specificity	Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.
Top Pathways	Complement and coagulation cascades, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Alteplase Gene - orb90758 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-PLAT-cDNA-Clone - DC02108 from Abgent, a WuXi AppTec company Prices $758.70 Sizes 10 µg Species Human Accession BC007231

PLAT - MBS1276019 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC007231

Human tPA transcript variant 1 Gene ORF cDNA clone in cloning vector - HG10157-M from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10157-ACG from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10157-CM from Sino Biological Species Human

Human tPAβ DNA transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG10157-M-N from Sino Biological Species Human Accession NM_000930.3

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10157-NH from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10157-ACR from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10157-M-F from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid - HG10157-UT from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10157-CY from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10157-CH from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10157-NF from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10157-CF from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10157-NM from Sino Biological Species Human

Human tPA transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10157-NY from Sino Biological Species Human

Human tPAβ DNA ORF clone(NM_000930.3) - CDCL186600 from Creative biogene Species Human

Human PLAT ORF Clone (BC007231) - CDCS406000 from Creative biogene Species Human Accession P00750

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