| Gene Symbol | KRT19 |
|---|---|
| Entrez Gene | 3880 |
| Alt Symbol | CK19, K19, K1CS |
| Species | Human |
| Gene Type | protein-coding |
| Description | keratin 19, type I |
| Other Description | 40-kDa keratin intermediate filament|CK-19|cytokeratin 19|cytokeratin-19|keratin, type I cytoskeletal 19|keratin, type I, 40-kd|keratin-19 |
| Swissprots | Q96FV1 P08727 Q9P1Y4 Q6NW33 Q9BYF9 B2R874 Q5XG83 Q7L5M9 Q96A53 |
| Accessions | AAA36044 AAF27048 BAB40770 CBU30437 CBU83086 EAW60743 P08727 AB041267 BAA94607 AB041268 BAA94608 AK313261 BAG36071 BC002539 AAH02539 BC007628 AAH07628 BC010409 AAH10409 BC067744 AAH67744 BC084574 AAH84574 BG490639 BG750971 BP328445 DA068330 DQ892179 ABM83105 DQ895373 ABM86299 Y00503 CAA68556 NM_002276 NP_002267 |
| Function | Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269|PubMed:16000376}. |
| Tissue Specificity | Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. {ECO:0000269|PubMed:16000376, ECO:0000269|PubMed:2468493, ECO:0000269|PubMed:2469734}. |
Cytokeratin 19 CRISPR/Cas9 KO Plasmid (h) - sc-400281 from Santa Cruz Biotechnology
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Cytokeratin 19 HDR Plasmid (h) - sc-400281-HDR from Santa Cruz Biotechnology
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Cytokeratin 19 Double Nickase Plasmid (h) - sc-400281-NIC from Santa Cruz Biotechnology
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Cytokeratin 19 Double Nickase Plasmid (h2) - sc-400281-NIC-2 from Santa Cruz Biotechnology
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Cytokeratin 19 CRISPR Activation Plasmid (h) - sc-400281-ACT from Santa Cruz Biotechnology
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Cytokeratin 19 CRISPR Activation Plasmid (h2) - sc-400281-ACT-2 from Santa Cruz Biotechnology
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Cytokeratin 19 Lentiviral Activation Particles (h) - sc-400281-LAC from Santa Cruz Biotechnology
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Cytokeratin 19 Lentiviral Activation Particles (h2) - sc-400281-LAC-2 from Santa Cruz Biotechnology
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Cytokeratin 19 siRNA (h) - sc-35152 from Santa Cruz Biotechnology
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Cytokeratin 19 shRNA Plasmid (h) - sc-35152-SH from Santa Cruz Biotechnology
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Cytokeratin 19 shRNA (h) Lentiviral Particles - sc-35152-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU115601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11366 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11366 from Sigma-Aldrich
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KRT19 siRNA (Human) - CRH2626 from Cohesion Biosciences
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Cytokeratin 19 CRISPR/Cas9 KO Plasmid (h2) - sc-400281-KO-2 from Santa Cruz Biotechnology
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Cytokeratin 19 HDR Plasmid (h2) - sc-400281-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human KRT19 (NM_002276.4) - SHH327315 from Creative biogene
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shRNA set against Human KRT19(NM_002276.4) - SHL205542 from Creative biogene
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KRT19 shRNA Plasmid (Human) - CHH2626 from Cohesion Biosciences
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KRT19 miRNA 3'UTR clone - MiUTR1H-05444 from Creative biogene
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