| Gene Symbol | Xrcc6 |
|---|---|
| Entrez Gene | 14375 |
| Alt Symbol | 70kDa, G22p1, Ku70 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | X-ray repair complementing defective repair in Chinese hamster cells 6 |
| Other Description | 5'-dRP/AP lyase Ku70|5'-deoxyribose-5-phosphate lyase Ku70|ATP-dependent DNA helicase 2 subunit 1|ATP-dependent DNA helicase II 70 kDa subunit|CTC box-binding factor 75 kDa subunit|CTC75|CTCBF|DNA repair protein XRCC6|Ku p70|X-ray repair cross-complementing protein 6|ku autoantigen protein p70 homolog|thyroid autoantigen 70 kDa |
| Swissprots | P23475 Q8QZX7 Q62453 Q6GTV8 Q3UJL8 Q62382 Q62027 O88212 |
| Accessions | AAC52675 AAC53575 EDL04536 EDL04537 P23475 AB010282 BAA28874 AF483500 AAL90774 AF483501 AAL90775 AK088530 AK143570 BAE25441 AK146392 BAE27135 AK146394 BAE27137 AK146396 BAE27139 AK178816 BC031422 AAH31422 BC051085 BY292222 M38700 AAA39396 Z14157 CAA78526 XM_006520440 XP_006520503 XM_006520442 XP_006520505 XM_006520443 XP_006520506 XM_006520444 XP_006520507 XM_006520445 XP_006520508 XM_011245456 XP_011243758 XR_383982 NM_010247 NP_034377 |
| Function | Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-d |
| Subcellular Location | Nucleus. Chromosome. |
| Top Pathways | Non-homologous end-joining |
Ku-70 CRISPR/Cas9 KO Plasmid (m) - sc-420441 from Santa Cruz Biotechnology
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Ku-70 HDR Plasmid (m) - sc-420441-HDR from Santa Cruz Biotechnology
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Ku-70 Double Nickase Plasmid (m) - sc-420441-NIC from Santa Cruz Biotechnology
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Ku-70 Double Nickase Plasmid (m2) - sc-420441-NIC-2 from Santa Cruz Biotechnology
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Ku-70 CRISPR Activation Plasmid (m) - sc-420441-ACT from Santa Cruz Biotechnology
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Ku-70 CRISPR Activation Plasmid (m2) - sc-420441-ACT-2 from Santa Cruz Biotechnology
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Ku-70 Lentiviral Activation Particles (m) - sc-420441-LAC from Santa Cruz Biotechnology
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Ku-70 Lentiviral Activation Particles (m2) - sc-420441-LAC-2 from Santa Cruz Biotechnology
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Ku-70 siRNA (m) - sc-35764 from Santa Cruz Biotechnology
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Ku-70 shRNA Plasmid (m) - sc-35764-SH from Santa Cruz Biotechnology
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Ku-70 shRNA (m) Lentiviral Particles - sc-35764-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU067171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN44749 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44749 from Sigma-Aldrich
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XRCC6 siRNA (Mouse) - CRM1452 from Cohesion Biosciences
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XRCC6 - MBS8233937 from MyBioSource
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shRNA set against Mouse XRCC6 (NM_010247.2) - SHH448144 from Creative biogene
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shRNA set against Mouse Xrcc6(NM_010247.2) - SHL139122 from Creative biogene
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Mouse XRCC6 siRNA - orb280928 from Biorbyt
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XRCC6 shRNA Plasmid (Mouse) - CHM1452 from Cohesion Biosciences
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XRCC6 miRNA 3'UTR clone - MiUTR1M-12860 from Creative biogene
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