| Gene Symbol |
Ppp4c
|
| Entrez Gene |
171366
|
| Alt Symbol |
Ppx
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 4, catalytic subunit
|
| Other Description |
PP4C|pp4|protein phosphatase 4 (formerly X), catalytic subunit|serine/threonine-protein phosphatase 4 catalytic subunit
|
| Swissprots |
Q5BJ92
|
| Accessions |
EDM17392 EDM17393 Q5BJ92 BC091574 AAH91574 FQ216602 M58443 AAA41930 XM_006230206 XP_006230268 NM_134359 NP_599186
|
| Function |
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
|
| Top Pathways |
Glucagon signaling pathway
|