| Gene Symbol | Elovl3 |
|---|---|
| Entrez Gene | 12686 |
| Alt Symbol | CIN-2, Cig30 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 |
| Other Description | 3-keto acyl-CoA synthase Elovl3|ELOVL FA elongase 3|ELOVL fatty acid elongase 3|cold inducible glycoprotein 30|cold-inducible glycoprotein of 30 kDa|elongation of very long chain fatty acids protein 3|elongation of very long chain fatty acids-like 3|very-long-chain 3-oxoacyl-CoA synthase 3 |
| Swissprots | O35949 |
| Accessions | AAD51088 EDL41980 O35949 AA241332 AK162271 BAE36829 BC016468 AAH16468 U97107 AAC06127 XM_006526624 XP_006526687 NM_007703 NP_031729 |
| Function | Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Participates in the formation of certain VLCFA and triglycerides in certain cells of the hair follicles and the sebaceous glands, required for skin barrier function. Critical enzyme for lipid accumulation and metabolic activity in brown adipocytes during the early phase of the tissue recruitment. Play a role in lipid storage and in resistance to diet-induced obesity. {ECO:0000269|PubMed:10791983, ECO:0000269|PubMed:14581464, |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10429212}; Multi-pass membrane protein {ECO:0000255}. |
| Tissue Specificity | Expressed in brown adipose tissue and liver. In the skin, strong expressed in the cells of the inner layer of the outer root sheath of the hair follicles and in the sebocytes of the sebaceous glands. Hardly detectable in the epidermis and not at all in fibroblasts. {ECO:0000269|PubMed:14581464, ECO:0000269|PubMed:9395518}. |
| Top Pathways | Fatty acid elongation |
ELOVL3 CRISPR/Cas9 KO Plasmid (m) - sc-419662 from Santa Cruz Biotechnology
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ELOVL3 HDR Plasmid (m) - sc-419662-HDR from Santa Cruz Biotechnology
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ELOVL3 Double Nickase Plasmid (m) - sc-419662-NIC from Santa Cruz Biotechnology
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ELOVL3 Double Nickase Plasmid (m2) - sc-419662-NIC-2 from Santa Cruz Biotechnology
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ELOVL3 CRISPR Activation Plasmid (m) - sc-419662-ACT from Santa Cruz Biotechnology
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ELOVL3 CRISPR Activation Plasmid (m2) - sc-419662-ACT-2 from Santa Cruz Biotechnology
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ELOVL3 Lentiviral Activation Particles (m) - sc-419662-LAC from Santa Cruz Biotechnology
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ELOVL3 Lentiviral Activation Particles (m2) - sc-419662-LAC-2 from Santa Cruz Biotechnology
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ELOVL3 siRNA (m) - sc-62268 from Santa Cruz Biotechnology
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ELOVL3 shRNA Plasmid (m) - sc-62268-SH from Santa Cruz Biotechnology
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ELOVL3 shRNA (m) Lentiviral Particles - sc-62268-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU042261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN30602 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30602 from Sigma-Aldrich
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ELOVL3 siRNA (Mouse) - CRM0704 from Cohesion Biosciences
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ELOVL3 - MBS8239740 from MyBioSource
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shRNA set against Mouse ELOVL3 (NM_007703.2) - SHH285273 from Creative biogene
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shRNA set against Mouse Elovl3(NM_007703.2) - SHH031709 from Creative biogene
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ELOVL3 shRNA Plasmid (Mouse) - CHM0704 from Cohesion Biosciences
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ELOVL3 miRNA 3'UTR clone - MiUTR1M-04371 from Creative biogene
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