ATP2A3

Gene Symbol ATP2A3
Entrez Gene 489
Alt Symbol SERCA3
Species Human
Gene Type protein-coding
Description ATPase, Ca++ transporting, ubiquitous
Other Description ATPase, Ca(2+)-transporting, ubiquitous|SR Ca(2+)-ATPase 3|adenosine triphosphatase, calcium|calcium pump 3|calcium-translocating P-type ATPase|sarco/endoplasmic reticulum Ca2+ -ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Swissprots O75501 O60901 Q16115 Q8TEX6 A8MZG0 D3DTJ8 Q93084 Q6JHX1 O60900 O75502 Q8TEX5
Accessions CAA75739 CAA75747 CAA75748 CAA93736 CDM55639 CDM55640 CDM55641 CDM55642 CDM55643 CDM55644 EAW90460 EAW90461 EAW90462 EAW90463 EAW90464 EAW90465 EAW90466 EAW90467 EAW90468 EAW90469 EAW90470 Q93084 AA643105 AF068220 AAC24525 AF068221 AAC24526 AF458228 AAL78967 AF458229 AAL78968 AK292716 BAF85405 AY460339 AAR15415 BC035729 AAH35729 DQ893317 ABM84243 EU176809 ABW03610 S68239 AAB29700 Z69881 CAA93737 XM_005256656 XP_005256713 XM_011523881 XP_011522183 XM_011523882 XP_011522184 XM_011523883 XP_011522185 XM_011523884 XP_011522186 XM_011523885 XP_011522187 XM_011523886 XP_011522188 XM_011523887 XP_011522189 XM_011523888 XP_011522190 XM_011523889 XP_011522191 XM_011523890 XP_011522192 XM_011523891 XP_011522193 XM_011523892 XP_011522194 NM_005173 NP_005164 NM_174953 NP_777613 NM_174954 NP_777614 NM_174955 NP_777615 NM_174956 NP_777616 NM_174957 NP_777617 NM_174958 NP_777618
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
Subcellular Location Nucleus membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}.
Tissue Specificity Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
Top Pathways Alzheimer's disease, Calcium signaling pathway, Pancreatic secretion, cGMP-PKG signaling pathway

SERCA3 CRISPR/Cas9 KO Plasmid (h) - sc-402840 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SERCA3 HDR Plasmid (h) - sc-402840-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SERCA3 Double Nickase Plasmid (h) - sc-402840-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SERCA3 Double Nickase Plasmid (h2) - sc-402840-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SERCA3 CRISPR Activation Plasmid (h) - sc-402840-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SERCA3 CRISPR Activation Plasmid (h2) - sc-402840-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SERCA3 Lentiviral Activation Particles (h) - sc-402840-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SERCA3 Lentiviral Activation Particles (h2) - sc-402840-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SERCA3 siRNA (h) - sc-41295 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SERCA3 shRNA Plasmid (h) - sc-41295-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SERCA3 shRNA (h) Lentiviral Particles - sc-41295-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SERCA3 ATPase RNAi - H00000489-R11 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SERCA3 ATPase RNAi - H00000489-R08 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SERCA3 ATPase RNAi - H00000489-R10 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SERCA3 ATPase RNAi - H00000489-R13 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU158301 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3688 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3688 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12701 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12701

ATP2A3 siRNA (Human) - CRH0343 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SERCA3 ATPase RNAi - H00000489-R14 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SERCA3 ATPase RNAi - H00000489-R09 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SERCA3 ATPase RNAi - H00000489-R12 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ATP2A3 - MBS8236823 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ATP2A3 (NM_174958.2) - SHH242626 from Creative biogene

Category siRNA
Species Reactivities Human
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