| Gene Symbol | Atp1a1 |
|---|---|
| Entrez Gene | 11928 |
| Alt Symbol | Atpa-1, BC010319 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ATPase, Na+/K+ transporting, alpha 1 polypeptide |
| Other Description | Na(+)/K(+) ATPase alpha-1 subunit|sodium pump subunit alpha-1|sodium/potassium-transporting ATPase subunit alpha-1 |
| Swissprots | Q8VDN2 Q91Z09 |
| Accessions | EDL07626 EDL07627 Q8VDN2 AK088000 AK137001 AK148989 BAE28712 AK150523 BAE29635 AK159279 BAE34957 AK159306 AK177206 AK177863 AK178999 AK179767 AK180023 AK180625 AK181228 AK181491 AK181532 AK182435 AK184412 AK184492 AK188707 AK189977 AK190187 AK190341 AK190533 AK190782 AK191059 AK191639 AK191797 AK191830 AK191920 AK191986 AK192305 AK192395 AK192706 AK192723 AK192966 AK193275 AK193322 AK194265 AK194308 AK194433 AK194599 AK194625 AK195171 AK195465 AK195858 AK195961 AK196342 AK196676 AK196990 AK197096 AK197178 AK197377 AK197399 AK197528 AK197675 AK197811 AK199023 AK199227 AK199691 AK199916 AK200318 AK200432 AK200443 AK200540 AK200949 AK201233 AK201496 AK201612 AK201641 AK202370 AK202506 AK202652 AK203269 AK203618 AK203691 AK203787 AK204336 AK204611 AK204844 AK205107 AK205182 AK205462 AK205718 AK205763 AK206258 AK207531 AK209160 AK209278 AK209648 AK209709 AK211215 AK211392 AK212020 AK213727 AK214941 AK215026 AK215727 AK216655 AK217701 AK218375 BB863666 BC010319 AAH10319 BC021496 AAH21496 BC023175 BC023794 AAH23794 BC023867 BC023964 BC025037 AAH25037 BC025618 AAH25618 BC025627 AAH25627 BC025811 AAH25811 BC030326 AAH30326 BC031176 BC031389 BC032187 AAH32187 BC033435 AAH33435 BC033471 AAH33471 BC034177 BC035352 BC042435 AAH42435 BE994800 NM_144900 NP_659149 |
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Melanosome {ECO:0000250}. |
| Top Pathways | Salivary secretion, Cardiac muscle contraction, cAMP signaling pathway, Aldosterone-regulated sodium reabsorption, Thyroid hormone synthesis |
Na + /K + -ATPase α1 CRISPR/Cas9 KO Plasmid (m) - sc-419236 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 HDR Plasmid (m) - sc-419236-HDR from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 Double Nickase Plasmid (m) - sc-419236-NIC from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 Double Nickase Plasmid (m2) - sc-419236-NIC-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 CRISPR Activation Plasmid (m) - sc-419236-ACT from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 CRISPR Activation Plasmid (m2) - sc-419236-ACT-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 Lentiviral Activation Particles (m) - sc-419236-LAC from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 Lentiviral Activation Particles (m2) - sc-419236-LAC-2 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 siRNA (m) - sc-36011 from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 shRNA Plasmid (m) - sc-36011-SH from Santa Cruz Biotechnology
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Na + /K + -ATPase α1 shRNA (m) Lentiviral Particles - sc-36011-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU045941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27185 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27185 from Sigma-Aldrich
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ATP1A1 siRNA (Mouse) - CRM0292 from Cohesion Biosciences
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ATP1A1 - MBS8239600 from MyBioSource
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shRNA set against Mouse ATP1A1 (NM_144900.2) - SHH242510 from Creative biogene
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ATP1A1 shRNA Plasmid (Mouse) - CHM0292 from Cohesion Biosciences
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