| Gene Symbol |
Trp53bp1
|
| Entrez Gene |
27223
|
| Alt Symbol |
53BP1, Tp53bp1, m53BP1, p53BP1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transformation related protein 53 binding protein 1
|
| Other Description |
murine p53-binding protein|p53-binding protein 1|transformation related protein 53 binding-protein 1|tumor suppressor p53-binding protein 1
|
| Swissprots |
Q8CI97 Q68FD0 P70399 Q91YC9
|
| Accessions |
EDL28044 EDL28045 P70399 AJ414734 CAC94013 AK029832 BAC26637 AK036324 BAC29383 AK045077 AK045416 AK045851 BAC32512 AK132323 BAE21103 AK148123 BAE28360 AK182369 BC035206 AAH35206 BC037378 BC079906 AAH79906 BE943701 BY777325 CA315900 CA316961 CA327869 CA752558 CD539142 CF744583 U67885 AAC52876 XM_006499661 XP_006499724 XM_006499662 XP_006499725 XM_006499666 XP_006499729 XM_006499667 XP_006499730 XM_006499668 XP_006499731 XM_011239581 XP_011237883 XM_011239582 XP_011237884 XM_011239583 XP_011237885 XM_011239584 XP_011237886 XM_011239585 XP_011237887 XR_866288 NM_001290830 NP_001277759 NM_013735 NP_038763
|
| Function |
Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11801725}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11801725}. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed (By similarity). {ECO:0000250}.
|