ANK2

Gene Symbol ANK2
Entrez Gene 287
Alt Symbol ANK-2, LQT4, brank-2
Species Human
Gene Type protein-coding
Description ankyrin 2, neuronal
Other Description ankyrin B|ankyrin, brain|ankyrin-2|ankyrin-2, nonerythrocytic|non-erythroid ankyrin
Swissprots Q08AC7 Q7Z3L5 Q08AC8 Q01485 Q01484
Accessions AAA62828 CCQ43128 EAX06287 EAX06288 EAX06289 EAX06290 EAX06291 EAX06292 Q01484 AF131823 AK021894 AK095596 AK128049 AK294720 BAH11860 AK299767 BAH13122 AK299815 BAH13137 AK299893 BAH13164 AK307601 AL706912 BC017986 BC047498 BC125235 AAI25236 BC125236 AAI25237 BQ716903 BQ890406 BX537758 CAD97827 BX538132 CAD98033 BX538239 CAD98077 CN259048 DQ925692 ABL59919 DQ925693 ABL59920 X56957 CAA40278 X56958 CAA40279 Z26634 CAB42644 XM_005262942 XP_005262999 XM_005262945 XP_005263002 XM_005262948 XP_005263005 XM_006714188 XP_006714251 XM_006714189 XP_006714252 XM_006714190 XP_006714253 XM_006714191 XP_006714254 XM_006714192 XP_006714255 XM_006714193 XP_006714256 XM_006714194 XP_006714257 XM_011531891 XP_011530193 NM_001127493 NP_001120965 NM_001148 NP_001139 NM_020977 NP_066187
Function In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (By similarity). Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate. {ECO:0000250, ECO:0000269|PubMed:12571597}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19007774}. Membrane {ECO:0000269|PubMed:19007774}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Apical cell membrane {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19007774}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Note=Expressed at the apical membrane of airway lung epithelial cells (By similarity). Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distict intracellular compartment of neonatal cardiomyocytes (By similarity). In skeletal muscle, localizes to neuromuscular junctions (By similarity). {ECO:0000250}.
Tissue Specificity Present in plasma membrane of neurons as well as glial cells throughout the brain. Expressed in fetal brain and in temporal cortex of adult brain. Also expressed in the inner segments of rod photoreceptors in retina. {ECO:0000269|PubMed:1830053, ECO:0000269|PubMed:1833308, ECO:0000269|PubMed:19007774}.
Top Pathways Proteoglycans in cancer

Ankyrin B (C-20) - sc-30519 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Ankyrin B (D-20) - sc-30517 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ankyrin B (D-20): sc-30517. Western blot analysis of Ankyrin B expression in SH-SY5Y (A) and BC<sub>3</sub>H1 (B) whole cell lysates.

Ankyrin B (H-300) - sc-28560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Ankyrin B (H-300): sc-28560. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

Ankyrin B (G-11) - sc-365757 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ankyrin B (G-11): sc-365757. Western blot analysis of Ankyrin B expression in Y79 whole cell lysate.

Ankyrin B (V-18) - sc-14995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Ankyrin B (V-18): sc-14995. Immunofluorescence staining of methanol-fixed BC<sub>3</sub>H1 cells showing cytoplasmic localization.

Ankyrin B (2.20) - sc-12718 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ankyrin B (2.20): sc-12718. Western blot analysis of Ankyrin B expression in Y79 (A) and SK-N-SH (B) whole cell lysates. Note lower molecular weight Ankyrin B degradation products.

Ankyrin B (3G7) - sc-70358 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Ankyrin B (3G7): sc-70358. Western blot analysis of Ankyrin B expression in TE 671 whole cell lysate (A) and rat brain (B) and mouse cerebellum (C) tissue extracts.

Anti-Ankyrin brain antibody [S105-13] - ab131419 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13
Overlay histogram showing SH-SY5Y cells stained with ab131419 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab131419, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in SH-SY5Y cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Ankyrin brain antibody [S10517] - N-terminal - ab192769 from Abcam

Prices $407.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone S10517
Lane 1 : Anti-Ankyrin brain antibody [S10517] - N-terminal (ab192769) at 1/1000 dilutionLane 2 : negative control (no primary antibody)Lane 1 : rat brain membrane lysateLane 2 : rat brain membrane lysatesLysates/proteins at 33 µg per lane.

Anti-ANK2 / Ankyrin B Antibody (Spectrin-Binding Domain, clone 22) - LS-C84788 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22

Anti-ANK2 / Ankyrin B Antibody - LS-C122672 from LifeSpan Bioscience

Prices $815.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Atto 565) - LS-C228610 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Atto 594) - LS-C228611 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Atto 488) - LS-C228609 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Atto 390) - LS-C228604 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Atto 633) - LS-C228612 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Atto 680) - LS-C228614 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, AP) - LS-C228615 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Atto 700) - LS-C228616 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Biotin) - LS-C228618 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, APC) - LS-C228617 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, Atto 655) - LS-C228613 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, FITC) - LS-C228619 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, PerCP) - LS-C228621 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13

Anti-ANK2 / Ankyrin B Antibody (aa203-496, clone S105-13, RPE) - LS-C228623 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S105-13
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